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Combined Gamma-Rays and Carbon-12 Nuclei Irradiation Modulates Brain Chemokine and Cytokine Production and Improves Spatial Learning in Tau P301S, but not 5xFAD Mouse Line

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Abstract

Earlier we showed the pro-cognitive effect of low doses of combined irradiation (including heavy charged particles) on Wistar rats. In the present work we studied the effect of irradiation (gamma-rays, 0.24 Gy; carbon-12, 0.18 Gy, 400 MeV/nucleon) on the course of neurodegenerative process using Tau P301S and 5xFAD transgenic mice lines, experimental models of Alzheimer’s disease. Irradiation led to an increase in pro- and anti-inflammatory cytokines and chemokines (IL-2, IL-6, IL-10, KC) in Tau P301S mice, but not in 5xFAD. At the same time, only the Tau P301S line was found to exhibit radiation-induced improvement in spatial learning.

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REFERENCES

  1. Bert, C., Engenhart-Cabillic, R., and Durante, M., Particle therapy for noncancer diseases, Med. Phys., 2012, vol. 39, no. 4, pp. 1716–1727.

    Article  PubMed  Google Scholar 

  2. Kokhan, V.S., Anokhin, P.K., Belov, O.V., et al., Cortical glutamate/GABA imbalance after combined radiation exposure: relevance to human deep-space missions, Neuroscience, 2019, vol. 416. pp. 295–308.

    Article  CAS  PubMed  Google Scholar 

  3. Perez, R.E., Younger, S., Bertheau, E., et al., Effects of chronic exposure to a mixed field of neutrons and photons on behavioral and cognitive performance in mice, Behav. Brain Res., 2020, vol. 379, p. 112377.

    Article  CAS  PubMed  Google Scholar 

  4. Whoolery, C.W., Yun, S., Reynolds, R.P., et al., Multi-domain cognitive assessment of male mice shows space radiation is not harmful to high-level cognition and actually improves pattern separation, Sci. Rep., 2020, vol. 10, no. 1, p. 2737.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Boyd, A., Byrne, S., Middleton, R.J., et al., Control of neuroinflammation through radiation-induced microglial changes, Cells, 2021, vol. 10, no. 9, p. 2381.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Yoshiyama, Y., Higuchi, M., Zhang, B., et al., Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model, Neuron, 2007, vol. 53, no. 3, pp. 337–351.

    Article  CAS  PubMed  Google Scholar 

  7. Jawhar, S., Trawicka, A., Jenneckens, C., et al., Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer’s disease, Neurobiol. Aging, 2012, vol. 33, no. 1, pp. 196e129–196e140.

  8. Spitz, D.R. and Hauer-Jensen, M., Ionizing radiation-induced responses: where free radical chemistry meets redox biology and medicine, Antioxid. Redox Signaling, 2014, vol. 20, no. 9, pp. 1407–1409.

    Article  CAS  Google Scholar 

  9. Kontush, A., Amyloid-beta: an antioxidant that becomes a pro-oxidant and critically contributes to Alzheimer’s disease, Free Radicals Biol. Med., 2001, vol. 31, no. 9, pp. 1120–1131.

    Article  CAS  Google Scholar 

  10. Shaftel, S.S., Kyrkanides, S., Olschowka, J.A., et al., Sustained hippocampal IL-1β overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology, J. Clin. Invest., 2007, vol. 117, no. 6, pp. 1595–1604.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Meraz-Rios, M.A., Toral-Rios, D., Franco-Bocanegra, D., et al., Inflammatory process in Alzheimer’s Disease, Front. Integr. Neurosci., 2013, vol. 7, p. 59.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Kokhan, V.S., Mariasina, S., Pikalov, V.A., et al., Neurokinin-1 receptor antagonist reverses functional CNS alteration caused by combined γ-rays and carbon nuclei irradiation, CNS Neurol. Disord.: Drug Targets, 2022, vol. 21, no. 3, pp. 278–289.

    Article  CAS  PubMed  Google Scholar 

  13. Chen, W., Abud, E.A., Yeung, S.T., et al., Increased tauopathy drives microglia-mediated clearance of beta-amyloid, Acta Neuropathol. Commun., 2016, vol. 4, no. 1, p. 63.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Alves, S., Churlaud, G., Audrain, M., et al., Interleukin-2 improves amyloid pathology, synaptic failure and memory in Alzheimer’s disease mice, Brain: J. Neurol., 2017, vol. 140, no. 3, pp. 826–842.

    Google Scholar 

  15. Lyra, E.S.N.M., Goncalves, R.A., Pascoal, T.A., et al., Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer’s disease, Transl. Psychiatry, 2021, vol. 11, no. 1, p. 251.

    Article  Google Scholar 

  16. Weston, L.L., Jiang, S., Chisholm, D., et al., Interleukin-10 deficiency exacerbates inflammation-induced tau pathology, J. Neuroinflammation, 2021, vol. 18, no. 1, p. 161.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Kang, M.H., **, Y.H., and Kim, B.S., Effects of keratinocyte-derived cytokine (CXCL-1) on the development of Theiler’s virus-induced demyelinating disease, Front. Cell Infect. Microbiol., 2018, vol. 8, p. 9.

    Article  PubMed  PubMed Central  Google Scholar 

  18. **, X. and Yamashita, T., Microglia in central nervous system repair after injury, J. Biochem., 2016, vol. 159, no. 5, pp. 491–496.

    Article  CAS  PubMed  Google Scholar 

  19. Parkhurst, C.N., Yang, G., Ninan, I., et al., Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor, Cell, 2013, vol. 155, no. 7, pp. 1596–1609.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Funding

The work was supported by the Russian Science Foundation, project no. 22-75-10036.

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Authors and Affiliations

  1. Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Moscow, Russia

    V. S. Kokhan

  2. Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia, settlement Svetlye Gory, Moscow Region, Russia

    M. S. Nesterov & A. I. Levashova

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  1. V. S. Kokhan
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  2. M. S. Nesterov
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  3. A. I. Levashova
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Corresponding author

Correspondence to V. S. Kokhan.

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COMPLIANCE WITH ETHICAL STANDARDS

The work was approved by the Bioethics Commission of the V.P. Serbsky Federal Medical Research Centre for Psychiatry and Narcology (Protocol no. 4 of November 16, 2022). The care and use of animals was governed by Directive 2010/63/EU of the European Parliament and European Council of September 22, 2010, on the protection of animals used for scientific purposes.

CONFLICT OF INTERESTS

The authors declare that they have no conflict of interest.

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Translated by E. V. Makeeva

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Kokhan, V.S., Nesterov, M.S. & Levashova, A.I. Combined Gamma-Rays and Carbon-12 Nuclei Irradiation Modulates Brain Chemokine and Cytokine Production and Improves Spatial Learning in Tau P301S, but not 5xFAD Mouse Line. Dokl Biol Sci 511, 255–258 (2023). https://doi.org/10.1134/S0012496623700424

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  • DOI: https://doi.org/10.1134/S0012496623700424

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