Abstract
A model of interaction between the human immunodeficiency virus and the human immune system is considered. Equilibria in the state space of the system and their stability are analyzed, and the ultimate bounds of the trajectories are constructed. It has been proved that the local asymptotic stability of the equilibrium corresponding to the absence of disease is equivalent to its global asymptotic stability. The loss of stability is shown to be caused by a transcritical bifurcation.
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REFERENCES
Kirschner, D., Lenhart, S., and Serbin, S., Dynamics of HIV infection of CD4+T cells, Math. Biosci., 1993, vol. 114, pp. 81–125.
Perelson, A.S. and Nelson, P.W., Mathematical analysis of HIV-1 dynamics in vivo, SIAM Rev., 1999, vol. 41, pp. 3–44.
Elaiw, A.M., Global properties of a class of HIV models, Nonlinear Anal. Real World Appl., 2010, vol. 11, pp. 2253–2263.
Hadjiandreou, M., Conejeros, R., and Vassiliadis, V.S., Towards a long-term model construction for the dynamic simulation of HIV infection, Math. Biosci. Eng., 2007, vol. 4, pp. 489–504.
De Leenheer, P. and Smith, H.L., Virus dynamics: A global analysis, SIAM J. Appl. Math., 2003, vol. 63, pp. 1313–1327.
Nowak, M. and May, R.M., Virus Dynamics: Mathematical Principles of Immunology and Virology, Oxford: Oxford Univ. Press, 2000.
Dehghan, M., Nasri, M., and Razvan, M.R., Global stability of a deterministic model for HIV infection in vivo, Chaos Solitons & Fractals, 2007, vol. 34, pp. 1225–1238.
Kirschner, D., Lenhart, S., and Serbin, S., Optimal control of the chemotherapy of HIV, J. Math. Biol., 1997, vol. 35, pp. 775–792.
Malinetskii, G.G., Matematicheskie osnovy sinergetiki (Mathematical Foundations of Synergetics), Moscow: URSS, 2017.
Krishchenko, A.P., Localization of invariant compact sets of dynamical systems, Differ. Equations, 2005, vol. 41, no. 12, pp. 1669–1676.
Kanatnikov, A.N. and Krishchenko, A.P., Invariantnye kompakty dinamicheskikh sistem (Invariant Compact Sets of Dynamical Systems), Moscow: Izd. MGTU im. N.E. Baumana, 2011.
Krishchenko, A.P., Behavior of trajectories of time-invariant systems, Differ. Equations, 2018, vol. 54, no. 11, pp. 1419–1424.
Khalil, H.K., Nonlinear Systems, Englewood Cliffs: Prentice Hall, 1996. Translated under the title: Nelineinye sistemy, Moscow–Izhevsk: Regulyarn. Khaoticheskaya Din., 2009.
Starkov, K.E. and Kanatnikov, A.N., Eradication conditions of infected cell populations in the 7-order HIV model with viral mutations and related results, Mathematics, 2021, vol. 9, p. 1862.
Kanatnikov, A.N. and Krishchenko, A.P., Iteration procedure of localization in a chronic Leukemia model, AIP Conf. Proc., 2020, p. 210004-1.
Chetaev, N.G., Ustoichivost’ dvizheniya (Motion Stability), Moscow: Nauka, 1965.
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This work was carried out with the support of the “Priority 2030” program of the Bauman Moscow State Technical University.
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Translated by V. Potapchouck
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Kanatnikov, A.N., Tkacheva, O.S. Behavior of Trajectories of a Four-Dimensional Model of HIV Infection. Diff Equat 59, 1451–1462 (2023). https://doi.org/10.1134/S00122661230110022
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DOI: https://doi.org/10.1134/S00122661230110022