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Radiomitigation Properties of α-Lipoic Acid when Used alone and in Combination with Metformin or Ethylmethylhydroxypyridine Succinate (Mexidol) in Mice after Exposure to X-ray Radiation

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Abstract

The radiomitigatory properties of α-lipoic acid and its use in combination with metformin and mexidol (ethylmethylhydroxypyridine succinate) in acute X-ray irradiation of animals have been studied. The study of radiation damage to the DNA of polychromatophilic erythrocytes of the red bone marrow of mice using a micronuclear test showed that α-lipoic acid had genoprotective and radiomitigatory properties in vivo. A study of the 30-day survival rate of mice exposed to a lethal dose confirmed that α-lipoic acid have radiomitigatory properties. The radiomitigatory effect of α-lipoic acid was concentration-dependent, and low doses of the drug were most effective. The radiomitigatory properties of α-lipoic acid were reduced in combination with mexidol and metformin.

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Funding

The work was carried out within the framework of the ITEB RAS State Task, project no. 075-01027-22-00.

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Authors and Affiliations

  1. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290, Pushchino, Moscow oblast, Russia

    E. E. Karmanova, A. V. Chernikov, A. M. Usacheva & V. I. Bruskov

  2. Institute of Cell Biophysics, Russian Academy of Sciences, 142290, Pushchino, Moscow oblast, Russia

    E. E. Karmanova

Authors
  1. E. E. Karmanova
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  2. A. V. Chernikov
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  3. A. M. Usacheva
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  4. V. I. Bruskov
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Correspondence to E. E. Karmanova.

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ETHICS APPROVAL AND CONSENT TO PARTICIPATE

All procedures with mice were carried out taking into account the international rules for working with laboratory animals and the requirements of the Commission on Biological Safety and Bioethics of the ITEB RAS (Minutes of the meeting of the Commission on Biological Safety and Bioethics of the ITEB RAS No. 25/2021 of February 09, 2021).

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The authors of this article declare that they have no conflicts of interest.

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Translated by E. Puchkov

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Abbreviations: LA, α-lipoic (thioctic) acid; EMHPS, ethylmethylhydroxypyridine succinate (mexidol); MF, metformin; PCE, polychromatophilic erythrocytes; LD, lethal dose; ALE average life expectancy.

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Karmanova, E.E., Chernikov, A.V., Usacheva, A.M. et al. Radiomitigation Properties of α-Lipoic Acid when Used alone and in Combination with Metformin or Ethylmethylhydroxypyridine Succinate (Mexidol) in Mice after Exposure to X-ray Radiation. BIOPHYSICS 68, 618–625 (2023). https://doi.org/10.1134/S0006350923040085

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