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Heat Shock Proteins in Cancer Diagnostics

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Abstract

With the growing number of cancer cases, new tools are required to obtain extensive molecular profiles of patients to help identify the disease. Early diagnosis of cancer is based on the analysis of relevant biomarkers, which can be used to monitor the population in order to identify the disease until it can be determined using standard methods and is not clinically manifest. Heat shock proteins, which act as molecular chaperones, are among the potential markers of cancer. Changes in heat shock protein expression can serve as an important diagnostic marker of the cell’s response to damage. This paper presents a brief overview of the prevalence of oncological diseases in the world, the need for the development of early oncological diagnostics, as well as the prospects for the use of heat shock proteins in making an oncological diagnosis.

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Funding

This work was funded by the Russian Science Foundation (project no. 19-14-00077).

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Authors and Affiliations

  1. Institute of Biochemistry and Physiology of Plants and Microorganisms – Subdivision of the Federal State Budgetary Research Institution Saratov Federal Scientific Centre of the Russian Academy of Sciences (IBPPM RAS), 410049, Saratov, Russia

    O. I. Guliy, S. A. Staroverov & L. A. Dykman

  2. Saratov State Vavilov Agrarian University, 410012, Saratov, Russia

    S. A. Staroverov

Authors
  1. O. I. Guliy
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  2. S. A. Staroverov
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  3. L. A. Dykman
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Correspondence to O. I. Guliy.

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This article does not contain any studies involving animals or human participants performed by any of the authors.

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Translated by A. Bulaev

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Guliy, O.I., Staroverov, S.A. & Dykman, L.A. Heat Shock Proteins in Cancer Diagnostics. Appl Biochem Microbiol 59, 395–407 (2023). https://doi.org/10.1134/S0003683823040063

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  • DOI: https://doi.org/10.1134/S0003683823040063

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