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A novel NUP98-PHF23 fusion resulting from a cryptic translocation t(11;17)(p15;p13) in acute myeloid leukemia

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References

  1. Slape C, Aplan PD . The role of NUP98 gene fusions in hematologic malignancy. Leuk Lymphoma 2004; 45: 1341–1350.

    Article  CAS  Google Scholar 

  2. Wysocka J, Swigut T, **ao H, Milne TA, Kwon SY, Landry J et al. A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Nature 2006; 442: 86–90.

    Article  CAS  Google Scholar 

  3. Shi X, Hong T, Walter KL, Ewalt M, Michishita E, Hung T et al. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature 2006; 442: 96–99.

    Article  CAS  Google Scholar 

  4. Eklund EA . The role of HOX genes in myeloid leukemogenesis. Curr Opin Hematol 2006; 13: 67–73.

    Article  CAS  Google Scholar 

  5. Hussey DJ, Dobrovic A . Recurrent coiled-coil motifs in NUP98 fusion partners provide a clue to leukemogenesis. Blood 2002; 99: 1097–1098.

    Article  CAS  Google Scholar 

  6. Jaju RJ, Fidler C, Haas OA, Strickson AJ, Watkins F, Clark K et al. A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15*5) in de novo childhood acute myeloid leukemia. Blood 2001; 98: 1264–1267.

    Article  CAS  Google Scholar 

  7. Rosati R, La Starza R, Veronese A, Aventin A, Schwienbacher C, Vallespi T et al. NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15). Blood 2002; 99: 3857–3860.

    Article  CAS  Google Scholar 

  8. Gurevich RM, Aplan PD, Humphries RK . NUP98-topoisomerase I acute myeloid leukemia-associated fusion gene has potent leukemogenic activities independent of an engineered catalytic site mutation. Blood 2004; 104: 1127–1136.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology and Program in Human Genetics, University of Maryland, Baltimore, MD, USA

    J C Reader, J S Meekins & Y Ning

  2. Department of Hematology-Oncology, University of Maryland, and Marlene and Stewart, Greenebaum Cancer Center, Baltimore, MD, USA

    I Gojo

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  1. J C Reader
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  2. J S Meekins
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  3. I Gojo
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  4. Y Ning
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Correspondence to Y Ning.

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Reader, J., Meekins, J., Gojo, I. et al. A novel NUP98-PHF23 fusion resulting from a cryptic translocation t(11;17)(p15;p13) in acute myeloid leukemia. Leukemia 21, 842–844 (2007). https://doi.org/10.1038/sj.leu.2404579

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