Abstract
AK155 is a recently discovered cytokine distantly related to IL-10. Its gene is located on chromosome 12q15, a region that is likely to harbour susceptibility genes for autoimmune and allergic diseases. We provide here identification and characterization of two microsatellite polymorphisms at the AK155 locus, ie D12S2511 and D12S2510. The first is located in the third intron and the second in the 3′ region of the gene. Both might be useful as markers in association or linkage studies of polygenic inflammatory or allergic diseases. No association with multiple sclerosis was found for each of these markers by means of the transmission disequilibrium test in an extended number of Sardinian simplex families.
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Knappe A, Hör S, Wittmann S, Fickenscher H Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with Herpesvirus Saimiri J Virol 2000 74 3881–3887
Dumoutier L, Van Roost E, Colau D, Renauld JC Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor Proc Natl Acad Sci USA 2000 97 10144–10149
Goris A, Epplen C, Fiten P et al Analysis of an IFN-gamma gene (IFNG) polymorphism in multiple sclerosis in Europe: effect of population structure on association with disease J Interferon Cytokine Res 1999 19 1037–1046
He B, Xu C, Yang B, Landtblom AM, Fredrikson S, Hillert J Linkage and association analysis of genes encoding cytokines and myelin proteins in multiple sclerosis J Neuroimmunol 1998 86 13–19
Satsangi J, Parkes M, Louis E et al Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptiblity loci on chromosomes 3, 7 and 12 Nat Genet 1996 14 199–202
Duerr RH, Barmada MM, Zhang L et al Linkage and association between inflammatory bowel disease and a locus on chromosome 12 Am J Hum Genet 1998 63 95–100
John S, Myerscough A, Marlow A et al Linkage of cytokine genes to rheumatoid arthritis. Evidence of genetic heterogeneity Ann Rheum Dis 1998 57 361–365
Ollier WER Role of interferon-γ gene in rheumatoid arthritits? Lancet 2000 356 784
Jahromi M, Millward A, Demaine A A CA repeat polymorphism of the IFN-gamma gene is associated with susceptibility to type 1 diabetes J Interferon Cytokine Res 2000 20 187–190
Bektas A, Suprenant ME, Wogan LT et al Evidence of a novel type 2 diabetes locus 50 cM centromeric to NIDDM2 on chromosome 12q Diabetes 1999 48 2246–2251
Los H, Koppelman GH, Postma DS The importance of genetic influences in asthma Eur Resp J 1999 14 1210–1227
Thomson G Map** disease genes: family-based association study Am J Hum Genet 1995 57 487–498
Merriman TR, Eaves IA, Twells RC, Merriman ME, Danoy PA, Muxworthy CE Transmission of haplotypes of microsatellite markers rather than single marker alleles in the map** of putative type 1 diabetes susceptibility gene (IDDM6) Hum Mol Genet 1998 7 517–524
Spielman RS, McGinnis RE, Ewens WJ Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM) Am J Hum Genet 1993 52 506–516
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KV is Allen J McClay Lecturer at QUB, UK.
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Goris, A., Marrosu, M. & Vandenbroeck, K. Novel polymorphisms in the IL-10 related AK155 gene (chromosome 12q15) . Genes Immun 2, 284–286 (2001). https://doi.org/10.1038/sj.gene.6363772
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DOI: https://doi.org/10.1038/sj.gene.6363772
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