Extended Data Fig. 5: Doxycycline suppresses inflammatory gene expression and metabolite levels in a time-dependent manner.
From: Tetracyclines promote survival and fitness in mitochondrial disease models
a, Heatmap of metabolites in ND1 cybrid cells that significantly change with doxycycline (Dox) and 7066 compared to DMSO, 7004, 7013, and CMT-3 (n = 3 biologically independent samples, p < 0.05, Student’s t-test with Bonferroni’s correction). b, Time-dependent gene expression of inflammatory markers in ND1 cybrid cells under galactose conditions (n = 3 biologically independent samples). c, Time-dependent metabolite changes in ND1 cybrid cells under galactose conditions (n = 3 biologically independent samples). Data are presented as mean values ± s.e.m. error bars, Student’s t-test with a two-stage linear step-up procedure of Benjamini, Krieger and Yekutieli, with Q = 5%, * q < 0.05.