Extended Data Fig. 4: Mitochondrial mutant cells have basally elevated cytokines under nutrient stress conditions which are suppressed by doxycycline.
From: Tetracyclines promote survival and fitness in mitochondrial disease models
a, Gene expression of inflammatory cytokine panel under high-glucose conditions for control (CON), ND1, and MELAS cybrid cells (n = 3 biologically independent samples). b, Gene expression of inflammatory cytokines in MELAS cybrid cells after 24 hour low-glucose (LG) conditions (n = 6 biologically independent samples). c, Gene expression of inflammatory cytokines in ND1 cybrid cells after 48 hours galactose (GAL) conditions (n = 3 biologically independent samples). Tetracycline analogues that rescue cell survival such as doxycycline, 7015, 7039, and 7066 suppress inflammatory gene expression. Data are presented as mean values ± s.e.m. error bars, Student’s t-test with a two-stage linear step-up procedure of Benjamini, Krieger and Yekutieli, with Q = 5%, * q < 0.05.