Extended Data Fig. 6: p38 inhibition partially mimics the doxycycline anti-inflammatory metabolomic signature.
From: Tetracyclines promote survival and fitness in mitochondrial disease models
a, Gene expression of inflammatory markers in ND1 cybrid cells treated with doxycycline (Dox) or p38i SB203580 after 48 hours galactose conditions (n = 4 biologically independent samples). b, Metabolite changes in doxycycline signature in ND1 cybrid cells treated with doxycycline or SB203580 after 48 hours galactose conditions (n = 4 biologically independent samples). c-d, Quantitation of GSSG/GSH and NADP+/NADPH ratio in ND1 cybrid cells with doxycycline or SB203580 treatment after 48 hours galactose conditions (n = 4 biologically independent samples). Data are presented as mean values ± s.e.m. error bars, Student’s t-test with a two-stage linear step-up procedure of Benjamini, Krieger and Yekutieli, with Q = 5%, * q < 0.05.