While skeletal editing stands as a powerful approach for simplifying synthetic procedures and obtaining complex molecules, viable methodologies remain limited. Now, a smart photoredox protocol, involving the insertion of carbon atoms into the indene core, gives access to a wide library of functionalized naphthalenes.
This is a preview of subscription content, log in via an institution to check access.
References
Joynson, B. W. & Ball, L. T. Helv. Chim. Acta 106, e202200182 (2023).
Jurczyk, J. et al. Nat. Synth. 1, 352–364 (2022).
Dherange, B. D. et al. J. Am. Chem. Soc. 143, 11337–11344 (2021).
Ciamician, G. L. & Dennstedt, M. Ber. Dtsch. Chem. Ges. 14, 1153–1163 (1881).
Wu, F.-P. et al. Nat. Catal. https://doi.org/10.1038/s41929-023-01089-x (2024).
Wang, Z. et al. Nature 554, 86–91 (2018).
Kelly, Q. P., Filatov, S. A. & Levin, D. M. Angew. Chem. Int. Ed. 61, e202213041 (2022).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Sicignano, M., Costa, P. Drug design via single-carbon atom insertion. Nat Catal 7, 224–226 (2024). https://doi.org/10.1038/s41929-024-01123-6
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41929-024-01123-6
- Springer Nature Limited