Extended Data Fig. 3: Differential Scanning Calorimetry of SMRZ-1.

a, Differential scanning calorimetry curve for SMRZ-1 in 20 mM Tris–HCl, 20 mM KCl, 1 mM MgCl₂, 0.1 mM CuSO₄ buffer, pH 7.4 at total strand concentrations with 88.7 μM SMRZ-1 RNA. The calculated T_m and ΔH are indicated in the box. b, The structures of the methyl donor SAM, SAH, and the protein methyltransferase inhibitor Sinefungin SFG.