Extended Data Fig. 7: Temporal organization of motor states.

a, Representation of transition probabilities between the three motor states during baseline (top) and during three periods occurring early (0–5 s), in the middle (10–15 s) or at the end (20–25 s) of the laser illumination (bottom) of D1/D2-SPNs (n = 21 mice), D2-SPNs (n = 15 mice), and D2 + D1/D2-SPNs (n = 11 mice), D1-SPNs (n = 16 mice), D1 + D1/D2-SPNs (n = 10 mice), and control D1/D2^eYFP-SPNs (n = 11 mice). For Laser ON condition, colored arrows indicate significant increases (solid lines) or decreases (dashed lines) in transition probabilities in comparison with baseline condition. b, Survival curves of ongoing locomotion (top panels), small movements (middle panels), and immobility (bottom panels) episodes when light stimulation starts (D1/D2, n = 21; D2, n = 15; D2 + D1/D2, n = 11; D1, n = 16; D1 + D1/D2, n = 10; D1/D2^eYFP, n = 11) (two-sided Kolmogorov-Smirnov test vs D1/D2^eYFP: *p < 0.05, **p < 0.01, ***p < 0.001). Detailed statistics are displayed in Supplementary Table 1. Source data are provided as a Source Data file.

Source data