Extended Data Fig. 4: Responding during non-reinforced sessions did not differ between groups prior to choice tests.
From: A molecularly integrated amygdalo-fronto-striatal network coordinates flexible learning and memory
All non-reinforced sessions were performed drug- and manipulation-free. (a) BLA→OFC inactivation (memory encoding): test 1 (time: F4,108 = 16.5, p < 0.001; time × CNO: F8,108 < 1), test 2 (time: F4,108 = 17.9, p < 0.001; time × CNO: F8,108 < 1), or test 3 (time: F4,108 = 16.2, p < 0.001; time × CNO: F8,108 < 1). (b) BLA→OFC inactivation (delayed memory encoding): test 1 (time: F4,56 = 29.9, p < 0.001; time × CNO: F4,56 < 1) or test 2 (time: F4,56 = 35.2, p < 0.001; time × CNO: F4,56 = 1.63, p = 0.179). (c) BLA→OFC inactivation (memory retrieval): test 1 (time: F4,64 = 12.2, p < 0.001; time × CNO: F4,64 < 1) or test 2 (time: F4,64 = 7.17, p < 0.001; time × CNO: F4,64 < 1). (d) BLA→OFC stimulation: test 1 (time: F4,112 = 16.3, p < 0.001; time × cocaine: F4,112 < 1; time × CNO: F4,112 = 1.18, p = 0.324; time × cocaine × CNO: F4,112 < 1), test 2 (time: F4,112 = 47.0, p < 0.001; time × cocaine: F4,112 = 2.61, p = 0.056; time × CNO: F4,112 = 2.19, p = 0.075; time × cocaine × CNO: F4,112 < 1), or test 3 (time: F4,112 = 55.2, p < 0.001; time × cocaine: F4,112 = 1.27, p = 0.284; time × CNO: F4,112 < 1; time × cocaine × CNO: F4,112 = 1.74, p = 0.147). (e) OFC→DMS inactivation: test 1 (time: F4,72 = 8.30, p < 0.001; time × CNO: F4, 72 < 1) or test 2 (time: F4,72 = 40.5, p < 0.001; time × CNO: F4,72 < 1). (f) OFC→BLA inactivation: test 1 (time: F4,56 = 20.8, p < 0.001; time × CNO: F4,56 < 1) or test 2 (time: F4,56 = 27.1, p < 0.001; time × CNO: F4,56 = 1.62, p = 0.183). (g-h) OFC memory trace inactivation: novel (time: F4,84 = 26.1, p < 0.001; time × 4OHT: F4,84 < 1) or familiar reinforcement conditions (time: F4,72 = 19.3, p < 0.001; time × 4OHT: F4,72 < 1). (i-j) BDNF-dependent circuit function: BLA-OFC (time: F4,136 = 61.6, p < 0.001; time × lateralization: F8,136 < 1) or OFC-DMS disconnections (time: F4,92 = 31.7, p < 0.001; time × lateralization: F8,92 < 1). Data presented as mean ± S.E.M. Correspondence to main figures noted.