RAPToR (real age prediction from transcriptome staging on reference) is a new, broadly applicable method that can precisely estimate the age of a sample from a reference transcriptome time series.
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References
Snoek, L. B. et al. A rapid and massive gene expression shift marking adolescent transition in C. elegans. Sci. Rep. 4, 3912 (2014). This article shows a striking number of expression profiling experiments that are affected by unintended developmental variation.
Saelens, W., Cannoodt, R., Todorov, H. & Saeys, Y. A comparison of single-cell trajectory inference methods. Nat. Biotechnol. 37, 547–554 (2019). This paper compares over 40 methods for trajectory inference from the transcriptome.
Francesconi, M. & Lehner, B. The effects of genetic variation on gene expression dynamics during development. Nature 505, 208–211 (2014). In this article, profiling data are reanalyzed taking into account unintended developmental spread.
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This is a summary of: Bulteau, R. & Francesconi, M. Real age prediction from the transcriptome with RAPToR. Nat. Methods https://doi.org/10.1038/s41592-022-01540-0 (2022).
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Inferring biological age from the transcriptome with RAPToR. Nat Methods 19, 936–937 (2022). https://doi.org/10.1038/s41592-022-01542-y
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DOI: https://doi.org/10.1038/s41592-022-01542-y
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