Log in

Bariatric metabolic surgery is associated with a lower risk for heart failure versus GLP-1RAs

  • Research Briefing
  • Published:

From Nature Medicine

View current issue Submit your manuscript
  • 1 Altmetric

In an observational cohort study of adults living with obesity and diabetes, we found that the primary incidence of congestive heart failure was lower in patients treated with bariatric metabolic surgery than in those on first-generation GLP-1 receptor agonists, an effect that was not explained by greater weight loss in the group that received bariatric metabolic surgery.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1: Cumulative hazards for CHF.

References

  1. Lauer, M. S., Anderson, K. M., Kannel, W. B. & Levy, D. The impact of obesity on left ventricular mass and geometry: the Framingham Heart Study. J. Am. Med. Assoc. 266, 231–236 (1991). This epidemiological study reports a strong association between body mass index and left ventricular hypertrophy.

    Article  CAS  Google Scholar 

  2. Drucker, D. J. Prevention of cardiorenal complications in people with type 2 diabetes and obesity. Cell Metab. 1, S1550–s4131 (2024). This review presents evidence on the use of treatments, including GLP-1RAs and BMS, for preventing complications in people with diabetes and/or obesity.

    Google Scholar 

  3. Vorsanger, M. H. et al. Cardiovascular effects of the new weight loss agents. J. Am. Coll. Cardiol. 68, 849–859 (2016). This review article summarizes data on the effects of GLP-1RAs on major cardiovascular risk factors, including weight loss.

    Article  CAS  PubMed  Google Scholar 

  4. Henry, J. A. et al. Changes in epicardial and visceral adipose tissue depots following bariatric surgery and their effect on cardiac geometry. Front. Endocrinol. 14, 1092777 (2023). This is a serial imaging study of adipose depots and cardiac geometry after bariatric surgery in 62 patients.

    Article  CAS  Google Scholar 

  5. Rassen, J. A., Murk, W. & Schneeweiss, S. Real-world evidence of bariatric surgery and cardiovascular benefits using electronic health records data: a lesson in bias. Diabetes Obes. Metab. 23, 1453–1462 (2021). This paper demonstrates the impact of information bias and confounding on results of the analyses of electronic health records.

    Article  PubMed  Google Scholar 

Download references

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Wolff Sagy, Y. et al. Effectiveness of bariatric metabolic surgery versus glucagon-like peptide-1 receptor agonists for prevention of congestive heart failure. Nat. Med. https://doi.org/10.1038/s41591-024-03052-0 (2024).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bariatric metabolic surgery is associated with a lower risk for heart failure versus GLP-1RAs. Nat Med (2024). https://doi.org/10.1038/s41591-024-03120-5

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/s41591-024-03120-5

  • Springer Nature America, Inc.

Navigation