Extended Data Fig. 5: Correlation of postmortem interval and longevity versus intensities of phosphorylation.
From: Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease
Intensity of phosphorylation of phospho-sites T181, S198/S199/S202, T217, T231, T231&S235, S262, S400/T403/S404 (ordinate) were correlated with postmortem interval53 (a) or age at death54 (b) (abscissa). n = 31 individual subjects. Two-tailed Spearman’s rank nonparametric correlation tests were used, and r coefficient and p values are indicated on the tables. c, Some phospho-epitopes do not correlate with seeding- Intensity of phosphorylation of phospho-sites T181, T217 and T231 (ordinate) were correlated with tau seeding activity (abscissa). n = 31 individual subjects. Two-tailed Spearman’s rank nonparametric correlation test was used, and r coefficient and p value are indicated on the plots.