Extended Data Fig. 5: Proliferation and apoptosis of immature iNKT cells is independent of BCL-6.
From: The transcription factor BCL-6 controls early development of innate-like T cells
a, Graphs show the percentage of EDU+ and Ki67+ cells in ST0 and ST1 cells in control littermates and Bcl6Δ/Δ mice. Data represent mean ± SEM. n = 3 independent experiments. b, FACS plots showing expression of IL-7 receptor and LEF1, in control littermates and Bcl6Δ/Δ mice. Experiments were repeated three times with identical results. c, Percentage of FLICA+ cells in the indicated iNKT cell stages, in control littermates and Bcl6Δ/Δ mice. Graphs show mean ± SEM. n = 3 independent experiments with 3 (control) and 4 (Bcl6Δ/Δ) mice. d, Flow cytometry plots showing the percent of total iNKT thymocytes, as Tetramer+TCRβ+ cells, in 10-days old control littermates and Bcl6Δ/Δ mice. e, Numbers and percentage of iNKT cells in the indicated mouse strains. Graphs represent mean ± SEM. n = 2 independent experiments with 5 control and 9 Bcl6Δ/Δ mice. * P < 0.05, ** P < 0.01, *** P < 0.001. Statistical analysis was performed with two-tailed unpaired t-test (a, e), or one-tailed unpaired t-test (c).