We developed a versatile lipid probe — MAO–SiR — to visualize the structure and dynamics of the inner mitochondrial membrane (IMM). MAO–SiR assembles in situ from two cell-permeant small molecules to image the IMM selectively, continuously and at super resolution for extended periods of time without extensive photobleaching or toxicity.
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This is a summary of: Zheng, S. et al. Long-term super-resolution inner mitochondrial membrane imaging with a lipid probe. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01450-y (2023).
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MAO–SiR is a tool for visualizing the inner workings of mitochondria. Nat Chem Biol 20, 15–16 (2024). https://doi.org/10.1038/s41589-023-01451-x
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DOI: https://doi.org/10.1038/s41589-023-01451-x
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