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SYNTHETIC BIOLOGY

Logic invades cell-free biosensing

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Cell-free biosensing is emerging as an effective and low-cost technology, but interpretation and synthesis of the results remains largely manual. Now, researchers have incorporated a new information-processing layer between biosensors and their outputs using logic gates to integrate complex results.

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Fig. 1: Information processing layer between biosensor and output.

References

  1. Zhang, D. Y. & Seelig, G. Nat. Chem. 3, 103–113 (2011).

    Article  CAS  Google Scholar 

  2. Zhao, S. et al. Nanoscale Horiz. 6, 298–310 (2021).

    Article  CAS  Google Scholar 

  3. Jung, J. K., Archuleta, C. M., Alam, K. K. & Lucks, J. B. Nat. Chem. Biol. https://doi.org/10.1038/s41589-021-00962-9 (2022).

    Article  PubMed  Google Scholar 

  4. Jung, J. K. et al. Nat. Biotechnol. 38, 1451–1459 (2020).

    Article  CAS  Google Scholar 

  5. Rodríguez-Serrano, A. F. & Hsing, I. M. ACS Synth. Biol. 10, 371–378 (2021).

    Article  Google Scholar 

  6. Qian, L. & Winfree, E. Science 332, 1196–1201 (2011).

    Article  CAS  Google Scholar 

  7. Schaffter, S. W. et al. Nucleic Acids Res. 46, 5332–5343 (2018).

    Article  CAS  Google Scholar 

  8. Mitchler, M. M., Garcia, J. M., Montero, N. E. & Williams, G. J. Curr. Opin. Biotechnol. 69, 172–181 (2021).

    Article  CAS  Google Scholar 

  9. Nguyen, P. Q. et al. Nat. Biotechnol. 39, 1366–1374 (2021).

    Article  CAS  Google Scholar 

  10. Gräwe, A. et al. PLoS ONE 14, e0210940 (2019).

    Article  Google Scholar 

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Correspondence to Keith Pardee.

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Amalfitano, E., Pardee, K. Logic invades cell-free biosensing. Nat Chem Biol 18, 356–358 (2022). https://doi.org/10.1038/s41589-021-00963-8

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  • DOI: https://doi.org/10.1038/s41589-021-00963-8

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