Extended Data Fig. 6: Schematic used to derive the desired direction of therapeutic modulation using direction of genetic effect.
From: Development of a human genetics-guided priority score for 19,365 genes and 399 drug indications
An idealistic framework using direction of genetic effect to propose the direction of therapeutic modulation. Mutations which decrease gene function and subsequently increase disease risk model activator drugs and mutations which increase gene function and increase disease risk model inhibitor drugs.