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Decoding gene regulation with CRISPR perturbations

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Two CRISPR tools for combinatorial genetic perturbations reveal gene regulatory networks.

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Fig. 1: Two novel CRISPR tools to map genomic regulatory sequences.

References

  1. Pacalin, N. M. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-024-02213-3 (2024).

    Article  Google Scholar 

  2. Hsiung, C. C.-S. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-024-02224-0 (2024).

    Article  Google Scholar 

  3. Henikoff, S. & Ahmad, K. Protein Sci. 31, e4458 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Melnikov, A. et al. Nat. Biotechnol. 30, 271–277 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Arnold, C. D. et al. Science 339, 1074–1077 (2013).

    Article  CAS  PubMed  Google Scholar 

  6. Fulco, C. P. et al. Nat. Genet. 51, 1664–1669 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Najm, F. J. et al. Nat. Biotechnol. 36, 179–189 (2018).

    Article  CAS  PubMed  Google Scholar 

  8. Boettcher, M. et al. Nat. Biotechnol. 36, 170–178 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Gasperini, M. et al. Cell 176, 377–390.e19 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Microbiology and Immunology & UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA, USA

    Stefan Oberlin & Michael T. McManus

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  1. Stefan Oberlin
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  2. Michael T. McManus
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Correspondence to Michael T. McManus.

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The authors declare no competing interests.

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Oberlin, S., McManus, M.T. Decoding gene regulation with CRISPR perturbations. Nat Biotechnol (2024). https://doi.org/10.1038/s41587-024-02222-2

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