Extended Data Fig. 5: Life history of breast cancers in premenopausal patients.
From: Evolutionary histories of breast cancer and related clones
a–d, Phylogenetic trees and the corresponding geographical maps of clones detected in cancer and non-cancer lesions in four premenopausal breast cancer patients who underwent total mastectomy (KU539 (a), KU873 (b), KU957 (c), and KU582 (d)). All the representations follow those in Fig. 2a. LG, low grade DCIS; IG, intermediate grade DCIS; HG, high grade DCIS; UPD, uniparental disomy. e, Number of clones which had acquired each driver mutation in peripheral branches after MRCA emerged.