Extended Data Fig. 3: Subcutaneous injection of PRISM cell line pool.
a, The same PRISM pool of 498 cell lines used for MetMap500 profiling was tested using subcutaneous injection on a cohort of 6 mice. Survival curves compare animal survival difference between subcutaneous and intracardiac (IC) injections, P value calculated using two-sided, log-rank test. b, Total numbers of cell lines detected in animals from the subcutaneous and IC injections. Detected lines are coloured in pink and non-detected lines are coloured in light-blue. P value calculated using two-sided t-test. c, Scatter plot showing barcode-quantified tumorigenic potential and metastatic potential from subcutaneous and IC experiments respectively. d, Group1 of basal breast cancer pool (Extended Data Fig. 1a) was subjected to mammary fat pad injection, barcode quantitation through RNA-Seq, and cell number inference.