Extended Data Fig. 8: Phylogeny and conservation of MBD4/MECP2.
From: The emergence of the brain non-CpG methylation system in vertebrates
(a) Maximum likelihood phylogenetic tree of the Methyl-CpG Binding Domain family in animals, representing the full-version of Fig. 4b. Nodal supports represent 100 bootstrap nonparametric replications. On the right, protein domain structure of each clade, as defined by Pfam domains. MBD, Methyl Binding Domain (PF01429). HhH-GPD, Thymine glycosylase (PF00730). MBDa, p55-binding region of MBD2/3 (PF16564). MBD_C, MBD2/3 C-terminal domain (PF14048). zf-CXXC, zinc finger (PF02008). CTD, MECP2 C-Terminal Domain. TRD, MECP2 Transcriptional Repression Domain. (b) Domain presence in MBD4/MECP2 orthologues in several invertebrate genomes. Lack of the Thymine glycosylase domain is likely due to incomplete gene annotation or genome assembly gaps.