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Sensitive sensing of biomarkers in interstitial fluid

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A minimally invasive microneedle patch detects specific protein biomarkers in dermal interstitial fluid at high sensitivity via a needle-integrated immunoassay coupled with an ultrabright fluorescent label.

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Fig. 1: Microneedle patch for the detection of biomarkers in ISF.
Fig. 2: Strategies for the sampling of biomarkers in ISF.

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Authors and Affiliations

  1. School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA

    Youngeun Kim & Mark R. Prausnitz

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  1. Youngeun Kim
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  2. Mark R. Prausnitz
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Correspondence to Mark R. Prausnitz.

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Competing interests

M.R.P. is an inventor of patents licensed to companies develo** microneedle-based products, a paid advisor to companies develo** microneedle-based products, and a founder or shareholder of companies develo** microneedle-based products (Micron Biomedical). These potential competing interests have been disclosed and are managed by Georgia Tech.

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Kim, Y., Prausnitz, M.R. Sensitive sensing of biomarkers in interstitial fluid. Nat Biomed Eng 5, 3–5 (2021). https://doi.org/10.1038/s41551-020-00679-5

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