Log in

Potential selection of unrelated donor based on HLA-DPB1 T-cell epitope matching using data from a single-center analysis

  • Correspondence
  • Published:
Bone Marrow Transplantation Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Germany)

Instant access to the full article PDF.

Fig. 1: Flow chart of donor searches.

Data availability

The datasets generated and analysed during the current study are available from the corresponding author on reasonable request.

References

  1. Shouval R, Fein JA, Labopin M, Kröger N, Duarte RF, Bader P, et al. Outcomes of allogeneic haematopoietic stem cell transplantation from HLA-matched and alternative donors: a European Society for Blood and Marrow Transplantation registry retrospective analysis. Lancet Haematol. 2019;6:e573–84.

    Article  Google Scholar 

  2. Fleischhauer K, Shaw BE, Gooley T, Malkki M, Bardy P, Bignon J-D, et al. Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated-donor haemopoietic-cell transplantation: a retrospective study. Lancet Oncol. 2012;13:366–74.

    Article  CAS  Google Scholar 

  3. Dehn J, Spellman S, Hurley CK, Shaw BE, Barker JN, Burns LJ, et al. Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from the NMDP/CIBMTR. Blood. 2019;134:924–34.

    Article  CAS  Google Scholar 

  4. Shaw BE, Robinson J, Fleischhauer K, Madrigal JA, Marsh SGE. Translating the HLA-DPB1 T-cell epitope-matching algorithm into clinical practice. Bone Marrow Transpl. 2013;48:1510–2.

    Article  CAS  Google Scholar 

  5. Crocchiolo R, Mele L, Testi M, Scollo Chiara M, Murgia B, Rossi A, et al. Use of DPB1 T-cell epitope algorithm among italian transplant centers: A survey on behalf of Associazione Italiana di Immunogenetica e Biologia dei Trapianti. HLA. 2021;98:114–21.

    Article  Google Scholar 

  6. Crocchiolo R, Ciceri F, Fleischhauer K, Oneto R, Bruno B, Pollichieni S, et al. HLA matching affects clinical outcome of adult patients undergoing haematopoietic SCT from unrelated donors: a study from the Gruppo Italiano Trapianto di Midollo Osseo and Italian Bone Marrow Donor Registry. Bone Marrow Transpl. 2009;44:571–7.

    Article  CAS  Google Scholar 

  7. Zino E, Frumento G, Marktel S, Sormani MP, Ficara F, Di Terlizzi S, et al. A T-cell epitope encoded by a subset of HLA-DPB1 alleles determines nonpermissive mismatches for hematologic stem cell transplantation. Blood. 2004;103:1417–24.

    Article  CAS  Google Scholar 

  8. Crocchiolo R, Zino E, Vago L, Oneto R, Bruno B, Pollichieni S, et al. Nonpermissive HLA-DPB1 disparity is a significant independent risk factor for mortality after unrelated hematopoietic stem cell transplantation. Blood. 2009;114:1437–44.

    Article  CAS  Google Scholar 

  9. Pidala J, Lee SJ, Ahn KW, Spellman S, Wang H-L, Aljurf M, et al. Nonpermissive HLA-DPB1 mismatch increases mortality after myeloablative unrelated allogeneic hematopoietic cell transplantation. Blood. 2014;124:2596–606.

    Article  CAS  Google Scholar 

  10. Shaw BE, Logan BR, Spellman SR, Marsh SGE, Robinson J, Pidala J, et al. Development of an unrelated donor selection score predictive of survival after HCT: donor age matters most. Biol Blood Marrow Transpl. 2018;24:1049–56.

    Article  Google Scholar 

  11. Logan BR, Maiers MJ, Sparapani RA, Laud PW, Spellman SR, McCulloch RE, et al. Optimal donor selection for hematopoietic cell transplantation using bayesian machine learning. JCO Clin. Cancer Inform. 2021;5:494–507.

    Google Scholar 

  12. Tram K, Stritesky G, Wadsworth K, Ng J, Anasetti C, Dehn J. Identification of DPB1 permissive unrelated donors is highly likely. Biol Blood Marrow Transpl. 2017;23:81–6.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank all the healthcare workers of the Servizio di Immunoematologia e Medicina Trasfusionale and of the Centro Trapianti Midollo at the ASST Grande Ospedale Metropolitano Niguarda (Milano, Italy), their patients and their donors.

Author information

Authors and Affiliations

Authors

Contributions

RC was responsible for designing the study, collected data, performed analyses and wrote the manuscript; DG collected data and performed analyses; FDA contributed to writing the manuscript; GC and GL performed HLA ty**; BDM and GM were responsible for patients´ care; GG was responsible for patients´ care and for the unrelated donor search; SR supervised the analyses and provided scientific support. All the authors approved the final version of the manuscript.

Corresponding author

Correspondence to Roberto Crocchiolo.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Crocchiolo, R., Girgenti, D., D’Amico, F. et al. Potential selection of unrelated donor based on HLA-DPB1 T-cell epitope matching using data from a single-center analysis. Bone Marrow Transplant 57, 1626–1628 (2022). https://doi.org/10.1038/s41409-022-01775-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41409-022-01775-7

  • Springer Nature Limited

Navigation