![](http://media.springernature.com/m312/springer-static/image/art%3A10.1038%2Fs41409-022-01775-7/MediaObjects/41409_2022_1775_Fig1_HTML.png)
Data availability
The datasets generated and analysed during the current study are available from the corresponding author on reasonable request.
References
Shouval R, Fein JA, Labopin M, Kröger N, Duarte RF, Bader P, et al. Outcomes of allogeneic haematopoietic stem cell transplantation from HLA-matched and alternative donors: a European Society for Blood and Marrow Transplantation registry retrospective analysis. Lancet Haematol. 2019;6:e573–84.
Fleischhauer K, Shaw BE, Gooley T, Malkki M, Bardy P, Bignon J-D, et al. Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated-donor haemopoietic-cell transplantation: a retrospective study. Lancet Oncol. 2012;13:366–74.
Dehn J, Spellman S, Hurley CK, Shaw BE, Barker JN, Burns LJ, et al. Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from the NMDP/CIBMTR. Blood. 2019;134:924–34.
Shaw BE, Robinson J, Fleischhauer K, Madrigal JA, Marsh SGE. Translating the HLA-DPB1 T-cell epitope-matching algorithm into clinical practice. Bone Marrow Transpl. 2013;48:1510–2.
Crocchiolo R, Mele L, Testi M, Scollo Chiara M, Murgia B, Rossi A, et al. Use of DPB1 T-cell epitope algorithm among italian transplant centers: A survey on behalf of Associazione Italiana di Immunogenetica e Biologia dei Trapianti. HLA. 2021;98:114–21.
Crocchiolo R, Ciceri F, Fleischhauer K, Oneto R, Bruno B, Pollichieni S, et al. HLA matching affects clinical outcome of adult patients undergoing haematopoietic SCT from unrelated donors: a study from the Gruppo Italiano Trapianto di Midollo Osseo and Italian Bone Marrow Donor Registry. Bone Marrow Transpl. 2009;44:571–7.
Zino E, Frumento G, Marktel S, Sormani MP, Ficara F, Di Terlizzi S, et al. A T-cell epitope encoded by a subset of HLA-DPB1 alleles determines nonpermissive mismatches for hematologic stem cell transplantation. Blood. 2004;103:1417–24.
Crocchiolo R, Zino E, Vago L, Oneto R, Bruno B, Pollichieni S, et al. Nonpermissive HLA-DPB1 disparity is a significant independent risk factor for mortality after unrelated hematopoietic stem cell transplantation. Blood. 2009;114:1437–44.
Pidala J, Lee SJ, Ahn KW, Spellman S, Wang H-L, Aljurf M, et al. Nonpermissive HLA-DPB1 mismatch increases mortality after myeloablative unrelated allogeneic hematopoietic cell transplantation. Blood. 2014;124:2596–606.
Shaw BE, Logan BR, Spellman SR, Marsh SGE, Robinson J, Pidala J, et al. Development of an unrelated donor selection score predictive of survival after HCT: donor age matters most. Biol Blood Marrow Transpl. 2018;24:1049–56.
Logan BR, Maiers MJ, Sparapani RA, Laud PW, Spellman SR, McCulloch RE, et al. Optimal donor selection for hematopoietic cell transplantation using bayesian machine learning. JCO Clin. Cancer Inform. 2021;5:494–507.
Tram K, Stritesky G, Wadsworth K, Ng J, Anasetti C, Dehn J. Identification of DPB1 permissive unrelated donors is highly likely. Biol Blood Marrow Transpl. 2017;23:81–6.
Acknowledgements
We thank all the healthcare workers of the Servizio di Immunoematologia e Medicina Trasfusionale and of the Centro Trapianti Midollo at the ASST Grande Ospedale Metropolitano Niguarda (Milano, Italy), their patients and their donors.
Author information
Authors and Affiliations
Contributions
RC was responsible for designing the study, collected data, performed analyses and wrote the manuscript; DG collected data and performed analyses; FDA contributed to writing the manuscript; GC and GL performed HLA ty**; BDM and GM were responsible for patients´ care; GG was responsible for patients´ care and for the unrelated donor search; SR supervised the analyses and provided scientific support. All the authors approved the final version of the manuscript.
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Crocchiolo, R., Girgenti, D., D’Amico, F. et al. Potential selection of unrelated donor based on HLA-DPB1 T-cell epitope matching using data from a single-center analysis. Bone Marrow Transplant 57, 1626–1628 (2022). https://doi.org/10.1038/s41409-022-01775-7
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41409-022-01775-7
- Springer Nature Limited