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Utility of the 21-month neurodevelopmental outcome for predicting neurodevelopmental impairment at 36 months for preterm infants <29 weeks gestation

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Abstract

Objective

To determine the sensitivity and specificity of the 21-month neurodevelopmental outcome for predicting the presence of neurodevelopmental impairment at 36 months corrected age in a population of preterm infants under 29 weeks gestation.

Study design

This is a retrospective observational cohort study. Preterm infants born under 29 weeks gestation who were followed up at both 18–21 months and 36 months corrected age with outcome data available were enrolled.

Results

Overall, 713 preterm infants <29 weeks gestation and were included in the final analysis. The specificity of the 21-month assessment for predicting neurodevelopmental impairment at 36 months corrected age was 66% (95% confidence interval[CI] 62–71%) with a positive predictive value of 61% (95% CI 56–66%).

Conclusion

In preterm neonates born <29 weeks gestation, the 18–21 months corrected neurodevelopmental outcome had low specificity and positive predictive value for predicting the presence of neurodevelopmental impairment at 36 months corrected age.

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Acknowledgements

We thank the Department of Pediatrics, Alberta Children’s Hospital and Neonatal Follow-up Clinic program for ongoing research support.

Author information

Authors and Affiliations

  1. Division of Neonatology, Department of Pediatrics, Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada

    Stefani M. Doucette, Dianne Creighton & Abhay Lodha

  2. Alberta Health Services, Calgary, Alberta, Canada

    Stefani M. Doucette, Selphee Tang, Heather Kehler & Abhay Lodha

  3. Neonatal Follow-Up Clinic, Department of Pediatrics, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada

    Stefani M. Doucette, Selphee Tang, Heather Kehler & Abhay Lodha

  4. Department of Obstetrics and Gynecology, Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada

    Selphee Tang

  5. Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada

    Abhay Lodha

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Contributions

SMD: Conceptualization, methodology, writing initial manuscript. ST: Methodology, data curation, formal analysis, reviewed final version of the manuscript. HK: Methodology, data curation, reviewed final version of the manuscript. DC: Methodology, data interpretation, reviewed final version of the manuscript. AL: Conceptualization, methodology, supervision, reviewed final version of the manuscript.

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Correspondence to Abhay Lodha.

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Additional Information Please note that in accordance with the Alberta Health Services Data Disclosure Agreement, we are not able to provide or make available the data for any purpose to a third party without the prior written consent of Alberta Health Services, Calgary, Alberta.

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Doucette, S.M., Tang, S., Kehler, H. et al. Utility of the 21-month neurodevelopmental outcome for predicting neurodevelopmental impairment at 36 months for preterm infants <29 weeks gestation. J Perinatol 43, 1406–1412 (2023). https://doi.org/10.1038/s41372-023-01777-3

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