Log in

Conjoined twins: an obstetrician’s guide to prenatal care and delivery management

  • Article
  • Published:
Journal of Perinatology Submit manuscript

Abstract

Objective

Obstetricians infrequently encounter conjoined twins. Much of the clinical care literature focuses on postnatal management from a neonatology and pediatric surgery perspective; guidance on obstetrical management is limited. We outline steps for prenatal evaluation, obstetrical care, and delivery planning.

Study design

Experiences with two cases of conjoined twins.

Results

We identified several points throughout the planning, delivery, and postnatal process that are important to highlight for optimizing clinical outcome, patient safety, and parental satisfaction.

Conclusion

After diagnosis, patients should be referred to a center experienced in the management of conjoined twins. Specialists in fields including maternal fetal medicine, pediatric surgery, neonatology, and radiology play a vital role in the management of these patients. Early referral allows for timely family counseling and decision-making. Prenatal evaluation beyond the first trimester should include a detailed ultrasound, fetal echocardiogram, and fetal MRI. 3D printed life-sized models can improve delivery planning and patient understanding.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Germany)

Instant access to the full article PDF.

Fig. 1: Fetal MRI, case 1.
Fig. 2: Fetal MRI, Case 2.

Similar content being viewed by others

Data availability

Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.

References

  1. O’Brien P, Nugent M, Khalil A. Prenatal diagnosis and obstetric management. Semin Pediatr Surg. 2015;24:203–6.

    Article  Google Scholar 

  2. Parmekar S, McMullen L, Washington C, Arnold JL. Role of simulation in preparation for the care of conjoined twins-prenatal preparation to separation. Semin Perinatol. 2018;42:329–39.

    Article  Google Scholar 

  3. Sager EC, Thomas A, Sundgren NC. Conjoined twins: Pre-birth management, changes to NRP and transport. Semin Perinatol. 2018;42:321–8.

    Article  Google Scholar 

  4. Edmonds LD, Layde PM. Conjoined twins in the United States, 1970-1977. Teratology. 1982;25:301–8.

    Article  CAS  Google Scholar 

  5. Spitz L. Conjoined twins. Prenat Diagn. 2005;25:814–9.

    Article  Google Scholar 

  6. Mutchinick OM, Luna-Munoz L, Amar E, et al. Conjoined twins: a world-wide collaborative epidemiological study of the international clearinghouse for birth defects surveillance and research. Am J Med Genet C Semin Med Genet. 2011;157C:274.

    Article  Google Scholar 

  7. Tang Y, Zhu J, Zhou GX, Dai L, Wang YP, Liang J. An epidemiological study on conjoined twins in China, from 1996 to 2004. Zhonghua Yu Fang Yi Xue Za Zhi 2007;41(Suppl):146–9.

    PubMed  Google Scholar 

  8. Martínez-Frías ML, Bermejo E, Mendioroz J, Rodríguez-Pinilla E, Blanco M, Egüés J, et al. Epidemiological and clinical analysis of a consecutive series of conjoined twins in Spain. J Pediatr Surg. 2009;44:811–20.

    Article  Google Scholar 

  9. Spencer R. Theoretical and analytical embryology of conjoined twins: part I: embryogenesis. Clin Anat. 2000;13:36–53.

    Article  CAS  Google Scholar 

  10. Kaufman MH. The embryology of conjoined twins. Childs Nerv Syst. 2004;20:508–25.

    Article  CAS  Google Scholar 

  11. Brizot ML, Liao AW, Lopes LM, Okumura M, Marques MS, Krebs V, et al. Conjoined twins pregnancies: experience with 36 cases from a single center. Prenat Diagn. 2011;31:1120–5.

    CAS  PubMed  Google Scholar 

  12. Lam YH, Sin SY, Lam C, Lee CP, Tang MH, Tse HY. Prenatal sonographic diagnosis of conjoined twins in the first trimester: two case reports. Ultrasound Obstet Gynecol. 1998;11:289–91.

    Article  CAS  Google Scholar 

  13. Bonilla-Musoles F, Raga F, Bonilla F Jr, Blanes J, Osborne NG. Early diagnosis of conjoined twins using two-dimensional color Doppler and three-dimensional ultrasound. J Natl Med Assoc. 1998;90:552–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Hubinont C, Kollmann P, Malvaux V, Donnez J, Bernard P. First-trimester diagnosis of conjoined twins. Fetal Diagn Ther. 1997;12:185–7.

    Article  CAS  Google Scholar 

  15. Yang P, Wu C, Yeh G, Hsieh CT. Prenatal diagnosis of parapagus diprosopus dibrachius dipus twins with spina bifida in the first trimester using two- and three- dimensional ultrasound. Taiwan J Obstet Gynecol. 2015;54:780–3.

    Article  Google Scholar 

  16. Arnold J, Luton A, Davies J. Introduction: unique challenges in the care of conjoined twins. Semin Perinat. 2018;42:319–20.

    Article  Google Scholar 

  17. Willobee BA, Mulder M, Perez EA, et al. Predictors of in-hospital mortality in newborn conjoined twins. Surgery. 2019;166:854–60.

    Article  Google Scholar 

  18. Kingston CA, McHugh K, Kumaradevan J, Kiely EM, Spitz L. Imaging in the preoperative assessment of conjoined twins. Radiographics. 2001;21:1187–208.

    Article  CAS  Google Scholar 

  19. Collins RT,III, Weinberg PM, Gruber PJ, St John Sutton MG. Conjoined hearts in thoracopagus twins. Pediatr Cardiol. 2012;33:252–7.

    Article  Google Scholar 

  20. Fallon SC, Olutoye OO. The surgical principles of conjoined twin separation. Semin Perinatol. 2018;42:386–92.

    Article  Google Scholar 

  21. Mackenzie TC, Crombleholme TM, Johnson MP, et al. The natural history of prenatally diagnosed conjoined twins. J Pediatr Surg. 2002;37:303–9.

    Article  Google Scholar 

  22. Spitz L, Kiely EM. Experience in the management of conjoined twins. Br J Surg. 2002;89:1188–92.

    Article  CAS  Google Scholar 

  23. Marty CM, Carter BS. Ethics and palliative care in the perinatal world. Semin Fetal Neonatal Med. 2018;23:35–38.

    Article  Google Scholar 

  24. Thomas A, Johnson K, Placencia FX. An ethically-justifiable, practical approach to decision-making surrounding conjoined-twin separation. Semin Perinatol. 2018;42:381–5.

    Article  Google Scholar 

  25. Kukora S, Gollehon N, Weiner G, Laventhal N. Prognostic accuracy of antenatal neonatology consultation. J Perinatol. 2017;37:27–31.

    Article  CAS  Google Scholar 

  26. Haward MF, Gaucher N, Payot A, Robson K, Janvier A. Personalized decision making: practical recommendations for antenatal counseling for fragile neonates. Clin Perinatol. 2017;44:429–45.

    Article  Google Scholar 

  27. Carreker C, De Jong H, Javor V, Fox L, Jacome J, Johns C, et al. Family support and media considerations with conjoined twins. Semin Perinatol. 2018;42:393–401.

    Article  Google Scholar 

  28. Mathew RP, Francis S, Basti RS, Suresh HB, Rajarathnam A, Cunha PD, et al. Conjoined twins – role of imaging and recent advances. J Ultrason. 2017;17:259–66.

    Article  Google Scholar 

  29. Mitchell T, Cheng E, Jolley J, Delaney S. Successful induction of labor of late second trimester conjoined twins: an alternative to hysterotomy. Obstet Gynecol. 2014;123(2 Pt 2 Suppl 2):469–72.

    Article  Google Scholar 

  30. Bianchi DW, Crombleholme TM, D’Alton ME (eds). Conjoined twins. In: Fetology: Diagnosis & Management of the Fetal Patient. McGraw-Hill: New York; 2000. pp 893–9.

  31. Jacques L, Heinlein M, Ralph J, Pan A, Nugent M, Kaljo K, et al. Complication rates of dilation and evacuation and labor induction in second-trimester abortion for fetal indications: a retrospective cohort study. Contraception 2020;202:83–86.

    Article  Google Scholar 

  32. Kukora SK, Boss RD. Values-based shared decision-making in the antenatal period. Semin Fetal Neonatal Med. 2018;23:17–24.

    Article  Google Scholar 

  33. American Academy of Pediatrics and American Heart Association. Weiner GM, Zaichkin J (eds). Textbook of Neonatal Resuscitation (NRP), 7th Ed. American Academy of Pediatrics: Elk Grove Village (IL), 2016.

  34. Yamada NK, Fuerch JH, Halamek LP. Modification of the neonatal resuscitation program algorithm for resuscitation of conjoined twins. Am J Perinatol. 2016;33:420–4.

    PubMed  Google Scholar 

  35. Yamada NK, Fuerch JH, Halamek LP. Simulation-Based patient-specific multidisciplinary team training in preparation for the resuscitation and stabilization of conjoined twins. Am J Perinat. 2017;34:621–6.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Contributions

PG formulated the concept of the paper, wrote the entire manuscript, researched prior publications, and corresponded with the co-authors on their input. DP provided input on the manuscript. WW and ML created the images and models used in the described cases and provided input on the manuscript. NL provided input on the manuscript. GM provided input on the manuscript. AC helped with formulation of the concept behind the paper, researched prior publications and provided input on the manuscript. MT helped with formulation of the concept behind the paper, researched prior publications and provided input on the manuscript. All authors approved the final submitted version of the manuscript and agree to be accountable for all aspects of the work.

Corresponding author

Correspondence to Patricia S. Greco.

Ethics declarations

Conflict of interest

The authors declare no competing interests.

Ethics approval and consent to participate

This study was performed in accordance with the Declaration of Helsinki. Both patients signed consent to participate in this review.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Greco, P.S., Pitts, D., Weadock, W.J. et al. Conjoined twins: an obstetrician’s guide to prenatal care and delivery management. J Perinatol 41, 2424–2431 (2021). https://doi.org/10.1038/s41372-021-01107-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41372-021-01107-5

  • Springer Nature America, Inc.

Navigation