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Hybrid Treg cells: steel frames and plastic exteriors

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Regulatory T cells have the remarkable ability to suppress immune responses driven by different types of effector T cells. Two recent studies, documenting important functions for T-bet and IRF4 in regulatory T cells, demonstrate that this ability requires the expression of transcription factors typically associated with effector T cell function.

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Figure 1: Like effector T cells, Treg cells may undergo polarization in the periphery after exiting the thymus.

References

  1. Wilson, C.B., Rowell, E. & Sekimata, M. Nat. Rev. Immunol. 9, 91–105 (2009).

    Article  CAS  Google Scholar 

  2. Koch, M.A. et al. T-bet controls regulatory T cell homeostasis and function during type-1 inflammation. Nat. Immunol. 10, 595–602 (2009).

    Article  CAS  Google Scholar 

  3. Zheng, Y. et al. Nature 458, 351–356 (2009).

    Article  CAS  Google Scholar 

  4. Zhou, L. et al. Nature 453, 236–240 (2008).

    Article  CAS  Google Scholar 

  5. Mantel, P.Y. et al. PLoS Biol. 5, e329 (2007).

    Article  Google Scholar 

  6. Brustle, A. et al. Nat. Immunol. 8, 958–966 (2007).

    Article  Google Scholar 

  7. Bauquet, A.T. et al. Nat. Immunol. 10, 167–175 (2009).

    Article  CAS  Google Scholar 

  8. Izcue, A., Coombes, J.L. & Powrie, F. Annu. Rev. Immunol. 27, 313–338 (2009).

    Article  CAS  Google Scholar 

  9. Huehn, J. et al. J. Exp. Med. 199, 303–313 (2004).

    Article  CAS  Google Scholar 

  10. Ito, T. et al. Immunity 28, 870–880 (2008).

    Article  CAS  Google Scholar 

  11. Maynard, C.L. et al. Nat. Immunol. 8, 931–941 (2007).

    Article  CAS  Google Scholar 

  12. Sather, B.D. et al. J. Exp. Med. 204, 1335–1347 (2007).

    Article  CAS  Google Scholar 

  13. Fontenot, J.D., Gavin, M.A. & Rudensky, A.Y. Nat. Immunol. 4, 330–336 (2003).

    Article  CAS  Google Scholar 

  14. Komatsu, N. et al. Proc. Natl. Acad. Sci. USA 106, 1903–1908 (2009).

    Article  CAS  Google Scholar 

  15. Leppkes, M. et al. Gastroenterology 136, 257–267 (2009).

    Article  CAS  Google Scholar 

  16. Powrie, F. et al. Immunity 1, 553–562 (1994).

    Article  CAS  Google Scholar 

  17. Tsuji, M. et al. Science 323, 1488–1492 (2009).

    Article  CAS  Google Scholar 

  18. Cao, X. et al. Immunity 27, 635–646 (2007).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Sir William Dunn School of Pathology, University of Oxford, Oxford, UK

    Michael J Barnes & Fiona Powrie

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  1. Michael J Barnes
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  2. Fiona Powrie
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Barnes, M., Powrie, F. Hybrid Treg cells: steel frames and plastic exteriors. Nat Immunol 10, 563–564 (2009). https://doi.org/10.1038/ni0609-563

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