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Rwdd1, a Thymus Aging Related Molecule, Is a New Member of the Intrinsically Unstructured Protein Family

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Abstract

We had previously identified a novel protein termed Rwdd1 whose expression in thymus is decreased in aged or oxidatively stressed mice. In the present study, we found that Rwdd1 expressed in both prokaryotic and eukaryotic cells showed a slower migration rate on SDS-PAGE gel. In addition, Rwdd1 was more sensitive to proteinase proteolysis. Furthermore, being a highly acidic protein which contains an RWD domain, Rwdd1 shared a high level of sequence similarity with Gir2, a member of the intrinsically unstructured protein (IUP). These findings suggest that Rwdd1 is a novel member of the IUP family.

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Authors and Affiliations

  1. Department of Immunology, School of Basic Medicine, Peking Union Medical College, and Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Bei**g, 100005, China

    Ning Kang, Dai Chen, Lian Duan, Shirong Liu, Long Tang, Qingfeng Liu, Lianxian Cui & Wei He

  2. Department of Medical Molecular Biology, Gansu Academy of Medical Sciences, Lanzhou, 730050, China

    Li Wang

Authors
  1. Ning Kang
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  2. Dai Chen
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  3. Li Wang
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  4. Lian Duan
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  5. Shirong Liu
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  6. Long Tang
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  7. Qingfeng Liu
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  8. Lianxian Cui
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  9. Wei He
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Corresponding author

Correspondence to Wei He.

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Kang, N., Chen, D., Wang, L. et al. Rwdd1, a Thymus Aging Related Molecule, Is a New Member of the Intrinsically Unstructured Protein Family. Cell Mol Immunol 5, 333–339 (2008). https://doi.org/10.1038/cmi.2008.41

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  • DOI: https://doi.org/10.1038/cmi.2008.41

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