Reversal of Glycogenetic to Glycogenolytic Action of Desoxycorticosterone in Rats

Abstract

IT was shown in a series of papers from this Laboratory that desoxycorticosterone has in vitro, in the concentration of 1–5 mgm. per cent, an inhibitory effect on glycogen formation^{1– 4} of the isolated muscle, which has since been explained as a glycogenolytic action⁵. This was the more unexpected since it seems certain that this adrenal cortical steroid has in the intact animal a distinct glyco-genetic action^6–8. We therefore tried whether it might be possible to reverse also the glycogenetic activity of desoxycorticosterone in the intact animal by increasing the dose to an inhibitory or glycogenolytic one.