Abstract
Liver transplantation is complicated by specificmedical problems. Diabetes mellitus occurs in 4-20% ofpatients undergoing liver transplantation. Patients withprimary sclerosing cholangitis and ulcerative colitis experience up to a 13% incidence ofcolon cancer after transplantation. Lymphomas occur in1-3% of patients after transplantation and account for57% of malignancies occurring in adult patients. Atraumatic bone fractures occur in 22-38% ofpatients and neurological complications, includingseizures, headache, and neuropathy occur in 19-47% ofpatients following liver transplantation. Patients undergoing liver transplantation may experiencerecurrence of their primary liver disease: hepatitis B,hepatitis C, primary biliary cirrhosis, autoimmunehepatitis, or primary sclerosing cholangitis. In patients not receiving immunoprophylaxis aftertransplantation for chronic hepatitis B, recurrenthepatitis B is seen in up to 90% of patients. This canbe markedly reduced with hyperimmune globulinimmunoprophylaxis. Recurrent hepatitis C is seen in the majorityof patients; current treatment modalities areinadequate. Recurrence of primary biliary cirrhosis orprimary sclerosing cholangitis in the allograft isinfrequent. Autoimmune hepatitis may recur in up to 26% ofpatients following liver transplantation. Primarydisease recurrence in the allograft and preventivestrategies are discussed.
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Carson, K.L., Hunt, C.M. Medical Problems Occurring After Orthotopic Liver Transplantation. Dig Dis Sci 42, 1666–1674 (1997). https://doi.org/10.1023/A:1018853213442
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DOI: https://doi.org/10.1023/A:1018853213442