Abstract
We present the design, guided by theory to eighth order, and the first evaluation of a Fourier transform ion cyclotron resonance (FT-ICR) compensated trap. The purpose of the new trap is to reduce effects of the nonlinear components of the trap** electric field; those nonliner components introduce variations in the cyclotron frequency of an ion depending on its spatial position (its cyclotron and trap** mode amplitudes). This frequency spread leads to decreased mass resolving power and signal-to-noise. The reduction of the spread of cyclotron frequencies, as explicitly modeled in theory, serves as the basis for our design. The compensated trap shows improved signal-to-noise and at least a threefold increase in mass resolving power compared to the uncompensated trap at the same trap** voltage. Resolving powers (FWHH) as high as 1.7 × 107 for the [M + H]+ of vasopressin at m/z 1084.5 in a 7.0-tesla induction can be obtained when using trap compensation.
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Published online July 2, 2008
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Brustkern, A.M., Rempel, D.L. & Gross, M.L. An electrically compensated trap designed to eighth order for FT-ICR mass spectrometry. J Am Soc Mass Spectrom 19, 1281–1285 (2008). https://doi.org/10.1016/j.jasms.2008.05.016
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DOI: https://doi.org/10.1016/j.jasms.2008.05.016