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Corona discharge ionization ion mobility spectrometry for ultra-trace determination of methamphetamine extracted from urine and plasma samples by dispersive liquid–liquid microextraction

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Abstract

In this work, dispersive liquid–liquid microextraction (DLLME) based on high-density extraction solvent was applied as a simple, fast and sensitive method for extraction and preconcentration of methamphetamine from human plasma and urine samples. The efficiency of positive corona discharge ionization ion mobility spectrometry was investigated for direct analysis of the extracted analyte. Effective parameters on the extraction efficiency, such as type and volume of the extraction and disperser solvents, centrifugation time, and sample solution pH were optimized. Trichloromethane and isopropanol were selected as the extracting and disperser solvents, respectively. Under the optimized conditions, the linear dynamic range (R2 = 0.9969) was found to be 0.5–18 µg/L, and 0.15 µg/L was calculated as the limit of detection. The relative standard deviations of intra- and inter-day were obtained 4 and 10%, respectively, and finally, in the analysis of human plasma and urine samples, the extraction recovery was obtained 104%.

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Acknowledgements

The authors would like to acknowledge the Research Council of Isfahan University of Technology (IUT) and Center of Excellence in Sensor and Green Chemistry, Iran for providing the financial support of this work.

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Authors and Affiliations

  1. Department of Chemistry, Isfahan University of Technology, Isfahan, 84156-83111, Iran

    Parisa Darougheh, Mohammad R. Rezayat & Mohammad T. Jafari

  2. Department of Chemistry, Shahreza Branch, Islamic Azad University, P.O. Box 311-86145, Shahreza, Isfahan, Iran

    Elham Jazan

Authors
  1. Parisa Darougheh
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  2. Elham Jazan
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  3. Mohammad R. Rezayat
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  4. Mohammad T. Jafari
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Correspondence to Mohammad T. Jafari.

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Darougheh, P., Jazan, E., Rezayat, M.R. et al. Corona discharge ionization ion mobility spectrometry for ultra-trace determination of methamphetamine extracted from urine and plasma samples by dispersive liquid–liquid microextraction. ANAL. SCI. 38, 1533–1540 (2022). https://doi.org/10.1007/s44211-022-00188-2

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