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Surface molecularly imprinted solid-phase extraction for the determination of vancomycin in plasma samples using HPLC–MS/MS

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Abstract

Vancomycin is a glycopeptide antibiotic used to treat infections caused by Gram-positive bacteria. Due to the narrow therapeutic index of vancomycin, it is necessary to develop a sensitive and reliable analytical method to monitor the drug concentration in plasma. A novel method based on surface molecularly imprinted solid-phase extraction combined with liquid chromatography-tandem mass spectrometry for the determination of vancomycin in plasma sample was developed. The plasma sample was cleaned up through the solid-phase extraction process before the analysis. The calibration standard of vancomycin in plasma ranged between 1 and 100 ng/mL, and the correlation coefficient (r) was 0.9993. The average recoveries were from 94.3 to 104.0%, and the precision was less than 10.5%. The limit of detection and limit of quantification were 0.5 ng/mL and 1 ng/mL, respectively. The method validated was successfully used for the detection of vancomycin in mice after oral administration.

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Acknowledgements

This research was funded by the National Natural Science Foundation of China (32172908, 31572562) and Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (2019BT02N054).

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Authors and Affiliations

  1. National Reference Laboratory of Veterinary Drug Residues (SCAU), College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China

    Hao Zhou, Qianqian Chen, Limin He & Rong Liu

  2. Pearl River Fisheries Research Institute, Chinese Academic of Fishery Science, Guangzhou, 510380, China

    Hao Zhou

  3. College of Animal Science, Guizhou University, Guiyang, 550025, China

    Xuqin Song

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  1. Hao Zhou
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  2. Qianqian Chen
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  3. Xuqin Song
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  4. Limin He
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Correspondence to Rong Liu.

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Zhou, H., Chen, Q., Song, X. et al. Surface molecularly imprinted solid-phase extraction for the determination of vancomycin in plasma samples using HPLC–MS/MS. ANAL. SCI. 38, 1171–1179 (2022). https://doi.org/10.1007/s44211-022-00143-1

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