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Diagnostik und Therapie des Kolonkarzinoms

Diagnostic et traitement du cancer du côlon

Diagnostica e terapia del carcinoma del colon

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Schweizer Gastroenterologie Aims and scope

Zusammenfassung

In den vergangenen Jahren konnten wichtige neue Erkenntnisse zur Diagnose und Therapie des Kolonkarzinoms gewonnen werden, beginnend bei der Vorsorge und Früherkennung, über endoskopische und chirurgische Therapiestrategien bis hin zu onkologischen Behandlungen sowohl lokalisierter als auch fortgeschrittener Tumorstadien. Von entscheidender Bedeutung zur Entwicklung einer optimalen Behandlungsstrategie für jeden Patienten ist eine enge interdisziplinäre Zusammenarbeit aller beteiligten Fachdisziplinen. Dieses Review soll die aktuellen Therapiekonzepte beim Kolonkarzinom auf der Basis aktueller Studiendaten aufzeigen. Die Behandlung des Rektumkarzinoms unterscheidet sich im Vorgehen vom Kolonkarzinom und wird in diesem Artikel nicht behandelt.

Résumé

D’importantes nouvelles connaissances concernant le diagnostic et le traitement du cancer du côlon – à commencer par la prévoyance et du dépistage précoce aux stratégies de traitement endoscopiques et chirurgicales et aux traitements oncologiques des tumeurs au stade localisé et avancé – ont été acquises au cours des dernières années. Une coopération interdisciplinaire étroite de toutes les disciplines médicales impliquées est d’importance décisive pour le développement d’une stratégie de traitement optimale pour chaque patient.

Cet article d’aperçu doit présenter les concepts actuels de traitement du cancer du côlon, s’appuyant sur les données d’études disponibles aujourd’hui. Le traitement du carcinome rectal est différent de celui du carcinome du côlon, et il n’est pas discuté dans cet article.

Riassunto

Negli ultimi anni sono state acquistate nuove conoscenze sulla diagnosi e sulla terapia del carcinoma del colon, a partire dalla prevenzione e dalla diagnosi precoce, passando per le strategie terapeutiche endoscopiche e chirurgiche, fino ai trattamenti oncologici per i tumori sia localizzati che in fase avanzata. Una stretta collaborazione interdisciplinare tra tutte le discipline specialistiche coinvolte è di fondamentale importanza al fine di sviluppare una strategia di trattamento ottimale per ogni paziente. Questa rassegna si propone di illustrare gli attuali concetti terapeutici per il cancro del colon sulla base dei dati degli studi attuali. La terapia del carcinoma rettale differisce per procedura da quella del carcinoma del colon e non viene discussa in questo articolo.

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Literatur

  1. Krebsliga Schweiz (2022) Zahlen & Fakten. https://www.krebsliga.ch/ueber-krebs/zahlen-fakten. Zugegriffen: 25.09.2022

  2. Cancer Today (2020) Global cancer burden. https://gco.iarc.fr/today/home. Zugegriffen: 25.09.2022

  3. Missiaglia E, Jacobs B, D’Ario G, Di Narzo AF, Soneson C, Budinska E et al (2014) Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features. Ann Oncol 25(10):1995–2001

    Article  CAS  Google Scholar 

  4. Glebov OK, Rodriguez LM, Nakahara K, Jenkins J, Cliatt J, Humbyrd CJ et al (2003) Distinguishing right from left colon by the pattern of gene expression. Cancer Epidemiol Biomark Prev 12(8):755–762

    CAS  Google Scholar 

  5. Petrelli F, Tomasello G, Borgonovo K, Ghidini M, Turati L, Dallera P et al (2017) Prognostic survival associated with left-sided vs right-sided colon cancer: a systematic review and meta-analysis. JAMA Oncol 3(2):211–219

    Article  Google Scholar 

  6. Lee MS, Menter DG, Kopetz S (2017) Right versus left colon cancer biology: integrating the consensus molecular subtypes. J Natl Compr Cancer Netw 15(3):411–419

    Article  Google Scholar 

  7. Yamauchi M, Morikawa T, Kuchiba A, Imamura Y, Qian ZR, Nishihara R et al (2012) Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum. Gut 61(6):847–854

    Article  CAS  Google Scholar 

  8. Kaminski MF, Regula J, Kraszewska E, Polkowski M, Wojciechowska U, Didkowska J et al (2010) Quality indicators for colonoscopy and the risk of interval cancer. N Engl J Med 362(19):1795–1803

    Article  CAS  Google Scholar 

  9. Qumseya BJ, Wallace MB (2012) Advanced colorectal polyp detection techniques. Curr Gastroenterol Rep 14(5):414–420

    Article  Google Scholar 

  10. Barua I, Vinsard DG, Jodal HC, Løberg M, Kalager M, Holme Ø et al (2021) Artificial intelligence for polyp detection during colonoscopy: a systematic review and meta-analysis. Endoscopy 53(03):277–284

    Article  Google Scholar 

  11. Balmaña J, Balaguer F, Cervantes A, Arnold D, ESMO Guidelines Working Group (2013) Familial risk-colorectal cancer: ESMO clinical practice guidelines. Ann Oncol 24(Suppl 6):vi73–vi80

    Article  Google Scholar 

  12. Wittekind C (2010) TNM Klassifikation maligner Tumoren, 7. Aufl. Wiley, Weinheim

    Google Scholar 

  13. Wittekind C (2017) TNM-Klassifikation maligner Tumoren, 8. Aufl. VCH

  14. Pohl H, Srivastava A, Bensen SP, Anderson P, Rothstein RI, Gordon SR et al (2013) Incomplete polyp resection during colonoscopy-results of the complete adenoma resection (CARE) study. Gastroenterology 144(1):74–80.e1

    Article  Google Scholar 

  15. Thoguluva Chandrasekar V, Spadaccini M, Aziz M, Maselli R, Hassan S, Fuccio L et al (2019) Cold snare endoscopic resection of nonpedunculated colorectal polyps larger than 10 mm: a systematic review and pooled-analysis. Gastrointest Endosc 89(5):929–936.e3

    Article  Google Scholar 

  16. Chandan S, Facciorusso A, Ramai D, Deliwala S, Mohan BP, Kassab LL et al (2022) Snare tip soft coagulation (STSC) after endoscopic mucosal resection (EMR) of large (> 20 mm) non pedunculated colorectal polyps: a systematic review and meta-analysis. Endosc Int Open 10(01):E74–E81

    Article  Google Scholar 

  17. Moss A, Williams SJ, Hourigan LF, Brown G, Tam W, Singh R et al (2015) Long-term adenoma recurrence following wide-field endoscopic mucosal resection (WF-EMR) for advanced colonic mucosal neoplasia is infrequent: results and risk factors in 1000 cases from the Australian Colonic EMR (ACE) study. Gut 64(1):57–65

    Article  Google Scholar 

  18. Bosch SL, Teerenstra S, de Wilt JHW, Cunningham C, Nagtegaal ID (2013) Predicting lymph node metastasis in pT1 colorectal cancer: a systematic review of risk factors providing rationale for therapy decisions. Endoscopy 45(10):827–834

    Article  Google Scholar 

  19. Takezawa T, Hayashi Y, Shinozaki S, Sagara Y, Okada M, Kobayashi Y et al (2019) The pocket-creation method facilitates colonic endoscopic submucosal dissection (with video). Gastrointest Endosc 89(5):1045–1053

    Article  Google Scholar 

  20. Thorlacius H, Rönnow CF, Toth E (2019) European experience of colorectal endoscopic submucosal dissection: a systematic review of clinical efficacy and safety. Acta Oncol 58(sup1):S10–S14

    Article  Google Scholar 

  21. Aepli P, Criblez D, Baumeler S, Borovicka J, Frei R (2018) Endoscopic full thickness resection (EFTR) of colorectal neoplasms with the full thickness resection device (FTRD): clinical experience from two tertiary referral centers in Switzerland. United Eur Gastroenterol J 6(3):463–470

    Article  Google Scholar 

  22. Kuellmer A, Mueller J, Caca K, Aepli P, Albers D, Schumacher B et al (2019) Endoscopic full-thickness resection for early colorectal cancer. Gastrointest Endosc 89(6):1180–1189.e1

    Article  Google Scholar 

  23. Hürtgen SM, Schmitz G, Junge K, Breuer E, Tischendorf JJW (2019) Perforation as a delayed complication after endoscopic full-thickness resection in a recurrent adenoma of the sigmoid. Z Gastroenterol 57(2):156–159

    Google Scholar 

  24. Schmidt A, Beyna T, Schumacher B, Meining A, Richter-Schrag HJ, Messmann H et al (2018) Colonoscopic full-thickness resection using an over-the-scope device: a prospective multicentre study in various indications. Gut 67(7):1280–1289

    Article  Google Scholar 

  25. Köhler L, Eypasch E, Paul A, Troidl H (1997) Myths in management of colorectal malignancy. Br J Surg 84(2):248–251

    Google Scholar 

  26. Wells KO, Hawkins AT, Krishnamurthy DM, Dharmarajan S, Glasgow SC, Hunt SR et al (2017) Omission of adjuvant chemotherapy is associated with increased mortality in patients with T3N0 colon cancer with inadequate lymph node harvest. Dis Colon Rectum 60(1):15–21

    Article  Google Scholar 

  27. Roth AD, Delorenzi M, Tejpar S, Yan P, Klingbiel D, Fiocca R et al (2012) Integrated analysis of molecular and clinical prognostic factors in stage II/III colon cancer. J Natl Cancer Inst 104(21):1635–1646

    Article  CAS  Google Scholar 

  28. Quasar Collaborative Group, Gray R, Barnwell J, McConkey C, Hills RK, Williams NS et al (2007) Adjuvant chemotherapy versus observation in patients with colorectal cancer: a randomised study. Lancet 370(9604):2020–2029

    Article  Google Scholar 

  29. Schrag D, Rifas-Shiman S, Saltz L, Bach PB, Begg CB (2002) Adjuvant chemotherapy use for Medicare beneficiaries with stage II colon cancer. J Clin Oncol 20(19):3999–4005

    Article  CAS  Google Scholar 

  30. Böckelman C, Engelmann BE, Kaprio T, Hansen TF, Glimelius B (2015) Risk of recurrence in patients with colon cancer stage II and III: a systematic review and meta-analysis of recent literature. Acta Oncol 54(1):5–16

    Article  Google Scholar 

  31. André T, Boni C, Navarro M, Tabernero J, Hickish T, Topham C et al (2009) Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial. J Clin Oncol 27(19):3109–3116

    Article  Google Scholar 

  32. Sinicrope FA, Foster NR, Thibodeau SN, Marsoni S, Monges G, Labianca R et al (2011) DNA mismatch repair status and colon cancer recurrence and survival in clinical trials of 5‑fluorouracil-based adjuvant therapy. J Natl Cancer Inst 103(11):863–875

    Article  CAS  Google Scholar 

  33. Tejpar S, Saridaki Z, Delorenzi M, Bosman F, Roth AD (2011) Microsatellite instability, prognosis and drug sensitivity of stage II and III colorectal cancer: more complexity to the puzzle. J Natl Cancer Inst 103(11):841–844

    Article  Google Scholar 

  34. Booth CM, Nanji S, Wei X, Peng Y, Biagi JJ, Hanna TP et al (2016) Use and effectiveness of adjuvant chemotherapy for stage III colon cancer: a population-based study. J Natl Compr Cancer Netw 14(1):47–56

    Article  CAS  Google Scholar 

  35. André T, Meyerhardt J, Iveson T, Sobrero A, Yoshino T, Souglakos I et al (2020) Effect of duration of adjuvant chemotherapy for patients with stage III colon cancer (IDEA collaboration): final results from a prospective, pooled analysis of six randomised, phase 3 trials. Lancet Oncol 21(12):1620–1629

    Article  Google Scholar 

  36. Truninger K, Lugli A, Koeberle D (2022) Nachsorge nach koloskopischer Polypektomie und Therapie des kolorektalen Karzinoms. https://doi.emh.ch/smf.2022.09114. Zugegriffen: 24. Juli 2022 (Swiss Med Forum)

  37. Fong Y, Cohen AM, Fortner JG, Enker WE, Turnbull AD, Coit DG et al (1997) Liver resection for colorectal metastases. J Clin Oncol 15(3):938–946

    Article  CAS  Google Scholar 

  38. Gonzalez M, Poncet A, Combescure C, Robert J, Ris HB, Gervaz P (2013) Risk factors for survival after lung metastasectomy in colorectal cancer patients: a systematic review and meta-analysis. Ann Surg Oncol 20(2):572–579

    Article  Google Scholar 

  39. Mohamed F, Cecil T, Moran B, Sugarbaker P (2011) A new standard of care for the management of peritoneal surface malignancy. Curr Oncol 18(2):e84–e96

    Article  CAS  Google Scholar 

  40. Nordlinger B, Sorbye H, Glimelius B, Poston GJ, Schlag PM, Rougier P et al (2013) Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial. Lancet Oncol 14(12):1208–1215

    Article  CAS  Google Scholar 

  41. Kanemitsu Y, Shimizu Y, Mizusawa J, Inaba Y, Hamaguchi T, Shida D et al (2021) Hepatectomy followed by mFOLFOX6 versus hepatectomy alone for liver-only metastatic colorectal cancer (JCOG0603): a phase II or III randomized controlled trial. J Clin Oncol 39(34):3789–3799

    Article  CAS  Google Scholar 

  42. Imanishi M, Yamamoto Y, Hamano Y, Yamada T, Moriwaki T, Gosho M et al (2019) Efficacy of adjuvant chemotherapy after resection of pulmonary metastasis from colorectal cancer: a propensity score-matched analysis. Eur J Cancer 106:69–77

    Article  CAS  Google Scholar 

  43. Quénet F, Elias D, Roca L, Goéré D, Ghouti L, Pocard M et al (2021) Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus cytoreductive surgery alone for colorectal peritoneal metastases (PRODIGE 7): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol 22(2):256–266

    Article  Google Scholar 

  44. Adam R, Wicherts DA, de Haas RJ, Ciacio O, Lévi F, Paule B et al (2009) Patients with initially unresectable colorectal liver metastases: Is there a possibility of cure? J Clin Oncol 27(11):1829–1835

    Article  Google Scholar 

  45. Falcone A, Ricci S, Brunetti I, Pfanner E, Allegrini G, Barbara C et al (2007) Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest. J Clin Oncol 25(13):1670–1676

    Article  CAS  Google Scholar 

  46. Cremolini C, Casagrande M, Loupakis F, Aprile G, Bergamo F, Masi G et al (2017) Efficacy of FOLFOXIRI plus bevacizumab in liver-limited metastatic colorectal cancer: a pooled analysis of clinical studies by Gruppo Oncologico del Nord Ovest. Eur J Cancer 73:74–84

    Article  CAS  Google Scholar 

  47. Tomasello G, Petrelli F, Ghidini M, Russo A, Passalacqua R, Barni S (2017) FOLFOXIRI plus bevacizumab as conversion therapy for patients with initially unresectable metastatic colorectal cancer: a systematic review and pooled analysis. JAMA Oncol 3(7):e170278

    Article  Google Scholar 

  48. Modest DP, Martens UM, Riera-Knorrenschild J, Greeve J, Florschütz A, Wessendorf S et al (2019) FOLFOXIRI plus panitumumab as first-line treatment of RAS wild-type metastatic colorectal cancer: the randomized, open-label, phase II VOLFI study (AIO KRK0109). J Clin Oncol 37(35):3401–3411

    Article  CAS  Google Scholar 

  49. Tang W, Ren L, Liu T, Ye Q, Wei Y, He G et al (2020) Bevacizumab plus mFOLFOX6 versus mFOLFOX6 alone as first-line treatment for RAS mutant unresectable colorectal liver-limited metastases: the BECOME randomized controlled trial. J Clin Oncol 38(27):3175–3184

    Article  CAS  Google Scholar 

  50. Ye LC, Liu TS, Ren L, Wei Y, Zhu DX, Zai SY et al (2013) Randomized controlled trial of cetuximab plus chemotherapy for patients with KRAS wild-type unresectable colorectal liver-limited metastases. J Clin Oncol 31(16):1931–1938

    Article  CAS  Google Scholar 

  51. Folprecht G, Gruenberger T, Bechstein W, Raab HR, Weitz J, Lordick F et al (2014) Survival of patients with initially unresectable colorectal liver metastases treated with FOLFOX/cetuximab or FOLFIRI/cetuximab in a multidisciplinary concept (CELIM study). Ann Oncol 25(5):1018–1025

    Article  CAS  Google Scholar 

  52. Holch JW, Ricard I, Stintzing S, Modest DP, Heinemann V (2017) The relevance of primary tumour location in patients with metastatic colorectal cancer: a meta-analysis of first-line clinical trials. Eur J Cancer 70:87–98

    Article  Google Scholar 

  53. Jeong JH, Kim J, Hong YS, Kim D, Kim JE, Kim SY et al (2017) HER2 amplification and cetuximab efficacy in patients with metastatic colorectal cancer harboring wild-type RAS and BRAF. Clin Colorectal Cancer 16(3):e147–e152

    Article  Google Scholar 

  54. Raghav K, Loree JM, Morris JS, Overman MJ, Yu R, Meric-Bernstam F et al (2019) Validation of HER2 amplification as a predictive biomarker for anti-epidermal growth factor receptor antibody therapy in metastatic colorectal cancer. JCO Precis Oncol 3:1–13

    Google Scholar 

  55. Arnold D, Lueza B, Douillard JY, Peeters M, Lenz HJ, Venook A et al (2017) Prognostic and predictive value of primary tumour side in patients with RAS wild-type metastatic colorectal cancer treated with chemotherapy and EGFR directed antibodies in six randomized trials. Ann Oncol 28(8):1713–1729

    Article  CAS  Google Scholar 

  56. Cremolini C, Antoniotti C, Rossini D, Lonardi S, Loupakis F, Pietrantonio F et al (2020) Upfront FOLFOXIRI plus bevacizumab and reintroduction after progression versus mFOLFOX6 plus bevacizumab followed by FOLFIRI plus bevacizumab in the treatment of patients with metastatic colorectal cancer (TRIBE2): a multicentre, open-label, phase 3, randomised, controlled trial. Lancet Oncol 21(4):497–507

    Article  CAS  Google Scholar 

  57. Cremolini C, Antoniotti C, Stein A, Bendell J, Gruenberger T, Rossini D et al (2020) Individual patient data meta-analysis of FOLFOXIRI plus bevacizumab versus doublets plus bevacizumab as initial therapy of unresectable metastatic colorectal cancer. J Clin Oncol. https://doi.org/10.1200/JCO.20.01225

    Article  Google Scholar 

  58. Hamaguchi T, Takashima A, Mizusawa J, Shimada Y, Nagashima F, Ando M et al (2022) A randomized phase III trial of mFOLFOX7 or CapeOX plus bevacizumab versus 5‑FU/ l -LV or capecitabine plus bevacizumab as initial therapy in elderly patients with metastatic colorectal cancer: JCOG1018 study (RESPECT). J Clin Oncol 40(4_suppl):10

    Article  Google Scholar 

  59. Cunningham D, Lang I, Marcuello E, Lorusso V, Ocvirk J, Shin DB et al (2013) Bevacizumab plus capecitabine versus capecitabine alone in elderly patients with previously untreated metastatic colorectal cancer (AVEX): an open-label, randomised phase 3 trial. Lancet Oncol 14(11):1077–1085

    Article  CAS  Google Scholar 

  60. Feliu J, Escudero P, Llosa F, Bolaños M, Vicent JM, Yubero A et al (2005) Capecitabine as first-line treatment for patients older than 70 years with metastatic colorectal cancer: an oncopaz cooperative group study. J Clin Oncol 23(13):3104–3111

    Article  CAS  Google Scholar 

  61. Fuchs CS, Moore MR, Harker G, Villa L, Rinaldi D, Hecht JR (2003) Phase III comparison of two irinotecan dosing regimens in second-line therapy of metastatic colorectal cancer. J Clin Oncol 21(5):807–814

    Article  CAS  Google Scholar 

  62. Andre T, Shiu KK, Kim TW, Jensen BV, Jensen LH, Punt CJA et al (2021) Final overall survival for the phase III KN177 study: pembrolizumab versus chemotherapy in microsatellite instability-high/mismatch repair deficient (MSI-H/dMMR) metastatic colorectal cancer (mCRC). J Clin Oncol 39(15_suppl):3500

    Article  Google Scholar 

  63. Lenz HJ, Van Cutsem E, Limon ML, Wong KYM, Hendlisz A, Aglietta M et al (2022) First-line nivolumab plus low-dose ipilimumab for microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer: the phase II checkmate 142 study. J Clin Oncol 40(2):161–170

    Article  CAS  Google Scholar 

  64. Pietrantonio F, Morano F, Corallo S, Miceli R, Lonardi S, Raimondi A et al (2019) Maintenance therapy with panitumumab alone vs panitumumab plus fluorouracil-leucovorin in patients with RAS wild-type metastatic colorectal cancer: a phase 2 randomized clinical trial. JAMA Oncol 5(9):1268–1275

    Article  Google Scholar 

  65. Modest DP, Karthaus M, Fruehauf S, Graeven U, Müller L, König AO et al (2022) Panitumumab plus fluorouracil and folinic acid versus fluorouracil and folinic acid alone as maintenance therapy in RAS wild-type metastatic colorectal cancer: the randomized PANAMA trial (AIO KRK 0212). J Clin Oncol 40(1):72–82

    Article  CAS  Google Scholar 

  66. Tabernero J, Grothey A, Van Cutsem E, Yaeger R, Wasan H, Yoshino T et al (2021) Encorafenib plus cetuximab as a new standard of care for previously treated BRAF V600E-mutant metastatic colorectal cancer: updated survival results and subgroup analyses from the BEACON study. J Clin Oncol 39(4):273–284

    Article  CAS  Google Scholar 

  67. Siena S, Di Bartolomeo M, Raghav K, Masuishi T, Loupakis F, Kawakami H et al (2021) Trastuzumab deruxtecan (DS-8201) in patients with HER2-expressing metastatic colorectal cancer (DESTINY-CRC01): a multicentre, open-label, phase 2 trial. Lancet Oncol 22(6):779–789

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Klinik für Hämatologie und Onkologie Hirslanden Zürich, Klinik Hirslanden, Witellikerstr. 40, 8008, Zürich, Schweiz

    Ursula Bisang &  Panagiotis Samaras

  2. GastroZentrum Hirslanden, Klinik Hirslanden, Zürich, Schweiz

    Jonas Zeitz & Stefan Groth

  3. Chirurgisches Zentrum Zürich, Klinik Hirslanden, Zürich, Schweiz

    Matthias von Allmen & Paul Magnus Schneider

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  1. Ursula Bisang
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Correspondence to Panagiotis Samaras.

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U. Bisang, J. Zeitz, S. Groth, M. von Allmen, P.M. Schneider und P. Samaras geben an, dass kein Interessenkonflikt besteht.

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Bisang, U., Zeitz, J., Groth, S. et al. Diagnostik und Therapie des Kolonkarzinoms. Schweiz. Gastroenterol. 3, 130–143 (2022). https://doi.org/10.1007/s43472-022-00081-3

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