Abstract
The primary objective of this study is to develop a membrane designed to expedite the healing process of burns and wounds. In our approach, we use Bacterial nanocellulose (BNC) cultivated from a kombucha tea culture, along with gelatin to create a sustainable wound-healing membrane. From the FTIR, the functional groups of both the BNC and gelatine in the membrane were apparent. The hydrophilic nature of the membrane indicated by its contact angle of 78.4 ± 3.4° promotes skin regeneration, by facilitating cell spreading, attachment, and tissue growth. Studies on the antibacterial activity of the generated membrane have shown that it successfully inhibits the growth of bacterial species such as Staphylococcus aureus and E. coli. The BNCG membrane demonstrates over 90% biocompatibility in MTT assay results validating its safe use in skin regeneration post third-degree burns. The formulated BNCG membrane shows a 95% closure rate in the L929 cell line, outperforming the control.
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Mareeswari Paramasivan: conceptualization, data acquisition, formal analysis, writing—review and editing.
Shuvetha Priya S.: data acquisition, formal analysis, writing—original draft.
Niranjan Balaji K.: data acquisition, formal analysis, writing—original draft.
Varshini R.: data acquisition, formal analysis, writing—original draft.
Yugesh Prasanna B.: data acquisition, formal analysis, writing—original draft.
Monica Chingchuilin Gonmei: data acquisition, formal analysis, writing—original draft.
M. K. Padmanabhan: project administration, resources, funding, supervision, writing—review and editing
Roop L. Mahajan: conceptualization, project administration, resources, supervision, validation, visualization, writing, review and editing
Chithra Lekha P.: conceptualization, project administration, resources, sup, revision data curation, formal analysis, investigation, methodology, validation, visualization, writing—original draft, writing—review and editing.
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Paramasivan, M., S, S.P., K, N.B. et al. Biopolymer-based Sustainable Membrane for Skin Regeneration. Mater Circ Econ 6, 17 (2024). https://doi.org/10.1007/s42824-024-00112-1
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DOI: https://doi.org/10.1007/s42824-024-00112-1