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Current and Emerging Bioresorbable Metallic Scaffolds: An Insight into Their Development, Processing and Characterisation

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Abstract

Solid metals and their alloys have been widely used for synthesis and fabrication of the implants and stents replacing human tissues or their functions for a quite a long time. However, in recent years, the advent of bioresorbable metallic materials have played an important role in biomedical applications. Scaffolds have been utilized in tissue regeneration to facilitate the formation and growth of new tissues or organs where a balance between temporary mechanical support and mass transport (degradation and cell growth) is ideally achieved. Bioresorbable metallic scaffolds are designed to reduce adverse events related to permanent metallic implants by providing temporary mechanical support and subsequent complete resorption. In view of the importance of emerging bioresorbable biomaterials, a brief review about development, processing and characterisation of bioresorbable metallic scaffolds is presented here. Focus is placed on metals/alloys as material for scaffold preparation. First, fundamental aspects about biomaterials and metallic materials and their considerations related to scaffold development are established. Second, processing/fabrication methods of these materials are described and finally characterisation methods to establish suitability of scaffolds are presented.

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Acknowledgements

This research was funded by Ministry of Education (Tier1), Singapore, WBS# R 265-000-684-114.

Funding

This research was funded by Ministry of Education-Singapore, Grant no [WBS# R 265-000-684-114].

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  1. Ashwinkumaran Senthilkumar

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Senthilkumar, A., Gupta, M. Current and Emerging Bioresorbable Metallic Scaffolds: An Insight into Their Development, Processing and Characterisation. J Indian Inst Sci 102, 585–598 (2022). https://doi.org/10.1007/s41745-021-00276-8

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