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O-Benzoylhydroxylamines: A Versatile Electrophilic Aminating Reagent for Transition Metal-Catalyzed C–N Bond-Forming Reactions

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Abstract

Owing to the prevalence of nitrogen-containing compounds in natural products and important pharmaceutical agents, chemists, have actively searched for the development of efficient and selective methodologies allowing for the facile construction of carbon–nitrogen bonds. Over the last decade, transition metal-catalyzed C–N bond construction via electrophilic amination reaction has emerged as an attractive approach for the synthesis of various organic molecules and pharmaceuticals. Particularly, O-benzoylhydroxylamines as an electrophilic aminating agent have proven to be the best and most widely used in both academic and industrial research. In this review, we highlight the key contributions to the recent transition metal-catalyzed C–N bond formation reactions using O-benzoylhydroxylamines as an aminating agent and their relevant mechanistic insights.

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Acknowledgements

The authors are thankful to the Discipline of Pharmaceutical Sciences, College of Health Sciences, University of Kwa-Zulu Natal (UKZN), Durban, South Africa, for providing all the necessary facilities. R.K. gratefully acknowledges National Research Foundation-South Africa for funding this project (Grant No. 129247).

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  1. Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal (Westville), Durban, 4000, South Africa

    Sachin Balaso Mohite, Vishal Kumar, Rajshekhar Karpoormath & Shaik Baji Baba

  2. Department of Chemistry, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974, Republic of Korea

    Milan Bera

  3. Department of Chemistry, Vivekanand College, Kolhapur (Autonomous), Maharastra, 416003, India

    Arjun S. Kumbhar

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Mohite, S.B., Bera, M., Kumar, V. et al. O-Benzoylhydroxylamines: A Versatile Electrophilic Aminating Reagent for Transition Metal-Catalyzed C–N Bond-Forming Reactions. Top Curr Chem (Z) 381, 4 (2023). https://doi.org/10.1007/s41061-022-00414-5

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