Log in

Assessment of a fast challenge test with iodinated contrast media in allergic patients with anaphylaxis

  • letter to the editor
  • Published:
Allergo Journal International Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Lerondeau B, Trechot P, Waton J, Poreaux C, Luc A, Schmutz JL, et al. Analysis of cross-reactivity among radiocontrast media in 97 hypersensitivity reactions. J Allergy Clin Immunol. 2016;137(e4):633–5.

    Article  CAS  PubMed  Google Scholar 

  2. Vega F, Múgica MV, Bazire R, Argíz L, Belver MT, Friera A, et al. Adverse reactions to iodinated contrast media: safety of a study protocol that includes fast full-dose parenteral challenge tests searching for an alternative contrast media. Clin Exp Allergy. 2020;50:271–4.

    Article  PubMed  Google Scholar 

  3. Brown SG. Clinical features and severity grading of anaphylaxis. J Allergy Clin Immunol. 2004;114:371–6.

    Article  PubMed  Google Scholar 

  4. Clement O, Dewachter P, Mouton-Faivre C, Nevoret C, Guilloux L, Bloch Morot E, et al. Immediate Hypersensitivity to Contrast Agents: The French 5‑year CIRTACI Study. EClinicalMedicine. 2018;1:51–61.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Bircher AJ, Brockow K, Grosber M, Hofmeier KS. Late elicitation of maculopapular exanthemas to iodinated contrast media after first exposure. Ann Allergy Asthma Immunol. 2013;111(6):576–7.8.

  6. Voltolini S, Cofini V, Murzilli F, Bignardi D, Borro M, Calamari M, et al. Hypersensitivity reactions to iodinate contrast media in Italy: a retrospective study. Characteristics of patients and risk factors. Eur Ann Allergy Clin Immunol. 2022;54:60–7.

    Article  CAS  PubMed  Google Scholar 

  7. Yuan F, Zhang C, Sun M, Wu D, Cheng L, Pan B. et al. MRGPRX2 mediates immediate-type pseudo-allergic reactions induced by iodine-containing iohexol. Biomed Pharmacother. 2021;137:111323.

    Article  CAS  PubMed  Google Scholar 

  8. Mendoza A, Zonja B, Mastroianni N, Negreira N, López de Alda M, Pérez S, et al. Drugs of abuse, cytostatic drugs and iodinated contrast media in tap water from the Madrid region (central Spain): A case study to analyse their occurrence and human health risk characterization. Environ Int. 2016;86:107–18.

    Article  CAS  PubMed  Google Scholar 

  9. Kormos JL, Schulz M, Ternes TA. Occurrence of iodinated X‑ray contrast media and their biotransformation products in the urban water cycle. Environ Sci Technol. 2011;45:8723–32.

    Article  ADS  CAS  PubMed  Google Scholar 

  10. Yan H, Zhang T, Yang Y, Li J, Liu Y, Qu D, et al. Occurrence of iodinated contrast media (ICM) in water environments and their control strategies with a particular focus on iodinated by-products formation: A comprehensive review. J Environ Manage. 2023;351:11993111.

    Google Scholar 

  11. Vega F, Múgica MV, Argíz L, Bazire R, Belver MT, Friera A, et al. Protocol to prevent contrast-induced nephropathy in parenteral challenge tests for allergy evaluation of hypersensitivity reactions to iodinated contrast media. Clin Exp Allergy. 2020;50:1200–3.

    Article  PubMed  Google Scholar 

  12. Torres MJ, Trautmann A, Böhm I, Scherer K, Barbaud A, Bavbek S, et al. Practice parameters for diagnosing and managing iodinated contrast media hypersensitivity. Allergy. 2021;76:1325–39.

    Article  PubMed  Google Scholar 

  13. Trautmann A, Brockow K, Behle V, Stoevesandt J. Radiocontrast media hypersensitivity: skin testing differentiates allergy from nonallergic reactions and identifies a safe alternative as proven by intravenous provocation. J Allergy Clin Immunol Pract. 2019;7:2218–24.

    Article  CAS  PubMed  Google Scholar 

  14. Soria A, Masson N, Vial-Dupuy A, Gaouar H, Amsler E, Chollet-Martin S, et al. Allergological workup with half-dose challenge in iodinated contrast media hypersensitivity. Allergy. 2019;74:414–7.

    Article  PubMed  Google Scholar 

  15. Sese L, Gaouar H, Autegarden JE, Alari A, Amsler E, Vial-Dupuy A, et al. Immediate hypersensitivity to iodinated contrast media: diagnostic accuracy of skin tests and intravenous provocation test with low dose. Clin Exp Allergy. 2016;46:472–8.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Contributions

F. Vega conducted the prospective study, participated in all stages of the study and wrote the first draft of the article. A. Lopez-Raigada y M. V. Múgica collaborated to performed skin tests and drug challenge tests. R. Jimenez-Saiz y C. Blanco collaborated in conceptualization and methodology, and they supervised the study. All authors revised the article critically and approved the final version to be published.

Corresponding author

Correspondence to Francisco Vega MD PhD.

Ethics declarations

Conflict of interest

F. Vega, A. Lopez-Raigada, M. V. Múgica, R. Jimenez-Saiz and C. Blanco declare that they have no competing interests.

Ethical standards

This study was approved by the Committee of Research and Ethics “Comité de Ética de la Investigación con Medicamentos del Hospital Universitario de la Princesa” (approval number 3396). Informed consent was obtained from all individual participants included in the study.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Vega, F., Lopez-Raigada, A., Mugica, M.V. et al. Assessment of a fast challenge test with iodinated contrast media in allergic patients with anaphylaxis. Allergo J Int (2024). https://doi.org/10.1007/s40629-024-00285-w

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s40629-024-00285-w

Keywords

Navigation