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Ruolo dell’imaging medico nucleare nell’iperparatiroidismo

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L'Endocrinologo Aims and scope

Sommario

Le metodiche di imaging delle paratiroidi rivestono un ruolo di cruciale importanza nell’identificazione e nella localizzazione delle paratiroidi iperfunzionanti nei pazienti con iperparatiroidismo primario. L’adenoma singolo costituisce la causa più comune di iperparatiroidismo primario. Negli ultimi decenni, il trattamento chirurgico di scelta nella maggior parte dei casi di iperparatiroidismo primario è stato la paratiroidectomia minimamente invasiva (MIP). Una chirurgia efficace, in mani esperte, dipende da una corretta localizzazione preoperatoria del tessuto paratiroideo iperfunzionante. Una fallimentare localizzazione pre-chirurgica delle ghiandole paratiroidi iperfunzionanti spesso rende necessaria una cervicotomia esplorativa bilaterale, pratica chirurgica gravata da maggiori svantaggi e possibili complicanze rispetto alla MIP. L’imaging delle paratiroidi può essere utile prima del trattamento chirurgico anche in caso di iperparatiroidismo secondario o in forme ereditarie, come la MEN 1, 2, e 4, in quanto permette sia la corretta localizzazione delle paratiroidi in sede tipica, sia l’identificazione e la localizzazione delle ghiandole ectopiche e soprannumerarie. Inoltre, permettendo di localizzare le paratiroidi fisiologiche ne consente la loro salvaguardia durante la procedura chirurgica.

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Authors and Affiliations

  1. Department of Oncology and Nuclear Medicine, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia

    Petra Petranović Ovčariček & Marija Punda

  2. Thyroid Committee, European Association of Nuclear Medicine, Vienna, Austria

    Petra Petranović Ovčariček, Luca Giovanella & Alfredo Campennì

  3. Clinic for Nuclear Medicine and Competence Centre for Thyroid Diseases, Imaging Institute of Southern Switzerland, Bellinzona, Switzerland

    Luca Giovanella

  4. Clinic for Nuclear Medicine and Interdisciplinary Thyroid Centre, University Hospital and University of Zurich, Zurich, Switzerland

    Luca Giovanella

  5. U.O.C. Medicina Nucleare, A.O.U “Gaetano Martino”, Università di Messina, Messina, Italia

    Massimiliano Siracusa

  6. Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands

    Frederik A. Verburg

  7. Dosimetry Committee, European Association of Nuclear Medicine, Vienna, Austria

    Frederik A. Verburg

  8. Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini morfo-funzionali, Università di Messina, Messina, Italia

    Alfredo Campennì

Authors
  1. Petra Petranović Ovčariček
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  2. Luca Giovanella
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  3. Marija Punda
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  4. Massimiliano Siracusa
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  5. Frederik A. Verburg
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  6. Alfredo Campennì
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Corresponding author

Correspondence to Alfredo Campennì.

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Conflitto di interessi

Gli autori Petra Petranović Ovčariček, Luca Giovanella, Marija Punda, Massimiliano Siracusa, Frederik A. Verburg e Alfredo Campennì dichiarano di non avere conflitti di interesse.

Consenso informato

Gli autori dichiarano di avere ottenuto il consenso informato all’utilizzazione delle immagini.

Studi sugli animali

Gli autori di questo studio non hanno eseguito studi sugli animali.

Additional information

Proposta da A. Campennì.

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Petranović Ovčariček, P., Giovanella, L., Punda, M. et al. Ruolo dell’imaging medico nucleare nell’iperparatiroidismo. L'Endocrinologo 23, 269–274 (2022). https://doi.org/10.1007/s40619-022-01069-6

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