Abstract
Some viruses, such as human immunodeficiency virus, can infect several types of cell populations. The age of infection can also affect the dynamics of infected cells and the production of viral particles. In this work, we study a virus model with infection age and different types of target cells that takes into account the saturation effect in antibody-immune response and a general non-linear infection rate. We construct suitable Lyapunov functionals to show that the global dynamics of the model is completely determined by two parameters: the basic reproduction number of virus and the reproductive number of antibody response.
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This article was supported by Universidad Autónoma de Yucatán and Conacyt SNI under Grant Number 15284.
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Avila-Vales, E., Pérez, Á.G.C. Global properties of an age-structured virus model with saturated antibody-immune response, multi-target cells, and general incidence rate. Bol. Soc. Mat. Mex. 27, 26 (2021). https://doi.org/10.1007/s40590-021-00315-5
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DOI: https://doi.org/10.1007/s40590-021-00315-5