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Predictors of aortic pulse wave velocity in the elderly with severe aortic stenosis

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Abstract

Predictors of aortic pulse wave velocity (AoPWV) were not previously studied in the elderly with severe aortic stenosis (AS). We aimed to compare the AoPWV in these patients with matched controls and to study the predictors of AoPWV in this population. We measured the AoPWV during cardiac catheterisation in 40 patients with severe AS and 20 matched controls. AoPWV in both groups was similar (p = 0.198) and lied within normal reference value for age in 68 % of elderly with severe AS. Central systolic blood pressure (SBP) (adjusted β = 0.45, p = 0.001) and glomerular filtration rate (GFR) (adjusted β = −0.29, p = 0.023) were the only independent predictors of AoPWV in AS group. Central SBP >140 mmHg was the best predictor of abnormal AoPWV (≥14.6 m/s) with 100 % sensitivity and 70 % specificity, p < 0.001. Conclusion: AoPWV is not increased in the elderly with severe AS compared to controls, and lies within the reference value for age in the majority of these patients. Central SBP >140 mmHg best predicts abnormal AoPWV in the elderly with severe AS.

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Authors and Affiliations

  1. Department of Cardiology, West German Heart and Vascular Center, Essen University Hospital, Duisburg-Essen University, Hufelandstr. 55, 45147, Essen, Germany

    Karim El-Chilali, Till Neumann, Sultan Alotaibi, Philipp Kahlert & Raimund Erbel

  2. Department of Cardiology, Cairo University Hospitals, Cairo University, Cairo, Egypt

    Heba Farouk, Zeinab Ashour & Khaled Sorour

  3. Department of Cardiology, Assiut University Hospital, Assiut University, Asyut, Egypt

    Mohamed Abdelhafez

  4. Department of Cardiothoracic Surgery, West German Heart and Vascular Center, Essen University Hospital, Duisburg-Essen University, Essen, Germany

    Daniel Wendt, Matthias Thielmann & Heinz G. Jakob

Authors
  1. Karim El-Chilali
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  2. Heba Farouk
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  3. Mohamed Abdelhafez
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  4. Till Neumann
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  5. Sultan Alotaibi
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  6. Daniel Wendt
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  7. Matthias Thielmann
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  8. Heinz G. Jakob
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  9. Zeinab Ashour
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  10. Khaled Sorour
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  11. Philipp Kahlert
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  12. Raimund Erbel
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Correspondence to Karim El-Chilali.

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On behalf of all authors, the corresponding author states that there is no conflict of interest.

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The study was performed in compliance with the ethical standards of declaration of Helsenki and its amendments and the institutional ethical standards of Essen University Hospital.

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Informed consent was obtained from all participants or their legal representatives prior to inclusion in the study.

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El-Chilali, K., Farouk, H., Abdelhafez, M. et al. Predictors of aortic pulse wave velocity in the elderly with severe aortic stenosis. Aging Clin Exp Res 28, 519–525 (2016). https://doi.org/10.1007/s40520-015-0443-z

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  • DOI: https://doi.org/10.1007/s40520-015-0443-z

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