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Short-Term Variability of Both Brachial and Aortic Blood Pressure is Increased in Patients with Immune-mediated Chronic Inflammation

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Abstract

Introduction

Blood pressure (BP) variability (BPV) has emerged as an indicator of subclinical organ damage and an independent predictor of cardiovascular disease (CVD) morbidity and mortality in high-risk populations.

Aim

We aimed to assess short-term variability of both brachial and aortic BP in psoriasis, a common immune-mediated inflammatory disorder characterized by increased CVD risk.

Methods

Psoriasis patients and non-psoriasis individuals had their BP assessed throughout a 24 h period (Mobil-O-Graph device). Brachial and aortic BPV during the 24 h and the respective daytime and nighttime periods was calculated from relevant ambulatory BP profiles. In-house software was applied to automatically calculate average real variability (ARV) of brachial and aortic systolic (bSBP, aSBP) and diastolic BP (bDPB, aDBP), and the weighted standard deviation (wSD) of 24 h bSBP/aSBP. 24 h pulse wave velocity (PWV) and augmentation index (AIx) were used as widely applied markers of arterial stiffness.

Results

Psoriasis patients (n = 74) presented increased ARV of 24 h and daytime bSBP/aSBP, and increased ARV of 24 h and daytime bDBP/aDBP, compared to controls (n = 40). PWV and AIx correlated with ARV of 24 h bSBP/aSBP, daytime bSBP/aSBP, while PWV further correlated with ARV of nighttime aSBP. The observed associations with PWV, yet not AIx, with indices of BPV remained significant after adjusting for CVD risk factors.

Conclusions

This is the first study reporting increased 24 h variability of both brachial and aortic BP in psoriasis. The association of short-term BPV with arterial stiffness implies a potential role of BPV in terms of CVD risk stratification in patients with chronic immune-mediated inflammation.

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Data Availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Authors and Affiliations

  1. Second Medical Department, Hippokration General Hospital of Thessaloniki, Aristotle University of Thessaloniki, Thessaloniki, Greece

    Panagiota Anyfanti

  2. 3rd Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, Ring Road Nea Efkarpia, 56429, Thessaloniki, Greece

    Areti Triantafyllou, Antonios Lazaridis, Anastasia Malliora, Anastasia Margouta, Barbara Nikolaidou, Vasileios Kotsis & Eugenia Gkaliagkousi

  3. Medical School, Democritus University of Thrace, Alexandroupolis, Greece

    Agapi Chionidou

Authors
  1. Panagiota Anyfanti
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  2. Areti Triantafyllou
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  3. Antonios Lazaridis
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  4. Anastasia Malliora
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  9. Eugenia Gkaliagkousi
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Corresponding author

Correspondence to Eugenia Gkaliagkousi.

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The authors declare no conflict of interest.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Ethical approval

The study was approved by the Aristotle University Ethics Committee and held in accordance with the Declaration of Helsinki.

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No funding was received.

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Anyfanti, P., Triantafyllou, A., Lazaridis, A. et al. Short-Term Variability of Both Brachial and Aortic Blood Pressure is Increased in Patients with Immune-mediated Chronic Inflammation. High Blood Press Cardiovasc Prev (2024). https://doi.org/10.1007/s40292-024-00651-3

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