![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs40262-022-01159-6/MediaObjects/40262_2022_1159_Fig1_HTML.png)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs40262-022-01159-6/MediaObjects/40262_2022_1159_Fig2_HTML.png)
References
Buck SAJ, Koolen SLW, Mathijssen RHJ, de Wit R, van Soest RJ. Cross-resistance and drug sequence in prostate cancer. Drug Resist Updat. 2021;56: 100761. https://doi.org/10.1016/j.drup.2021.100761.
Mout L, van Royen ME, de Ridder C, Stuurman D, van de Geer WS, Marques R, et al. Continued androgen signalling inhibition improves cabazitaxel efficacy in prostate cancer. EBioMedicine. 2021;5(73): 103681. https://doi.org/10.1016/j.ebiom.2021.103681.
Belderbos BPS, Bins S, van Leeuwen RWF, Oomen-de Hoop E, van der Meer N, de Bruijn P, et al. Influence of enzalutamide on cabazitaxel pharmacokinetics: a drug-drug interaction study in metastatic castration-resistant prostate cancer (mCRPC) patients. Clin Cancer Res. 2018;24(3):541–6. https://doi.org/10.1158/1078-0432.CCR-17-2336.
Fizazi K, Shore N, Tammela TL, Ulys A, Vjaters E, Polyakov S, et al. Nonmetastatic, castration-resistant prostate cancer and survival with darolutamide. N Engl J Med. 2020;383(11):1040–9. https://doi.org/10.1056/NEJMoa2001342.
Zurth C, Koskinen M, Fricke R, Prien O, Korjamo T, Graudenz K, et al. Drug-drug interaction potential of darolutamide: in vitro and clinical studies. Eur J Drug Metab Pharmacokinet. 2019;44(6):747–59. https://doi.org/10.1007/s13318-019-00577-5.
de Bruijn P, de Graan AJ, Nieuweboer A, Mathijssen RH, Lam MH, de Wit R, et al. Quantification of cabazitaxel in human plasma by liquid chromatography/triple-quadrupole mass spectrometry: a practical solution for non-specific binding. J Pharm Biomed Anal. 2012;5(59):11–22. https://doi.org/10.1016/j.jpba.2011.10.010.
Eisenberger M, Hardy-Bessard AC, Kim CS, Geczi L, Ford D, Mourey L, et al. Phase III study comparing a reduced dose of cabazitaxel (20 mg/m2) and the currently approved dose (25 mg/m2) in postdocetaxel patients with metastatic castration-resistant prostate cancer: PROSELICA. J Clin Oncol. 2017;35(28):3198–206. https://doi.org/10.1200/JCO.2016.72.1076.
Davis ID, Martin AJ, Stockler MR, Begbie S, Chi KN, Chowdhury S, et al. Enzalutamide with standard first-line therapy in metastatic prostate cancer. N Engl J Med. 2019;381(2):121–31. https://doi.org/10.1056/NEJMoa1903835.
Fizazi K, Foulon S, Carles J, Roubaud G, McDermott R, Flechon A, et al. Abiraterone plus prednisone added to androgen deprivation therapy and docetaxel in de novo metastatic castration-sensitive prostate cancer (PEACE-1): a multicentre, open-label, randomised, phase 3 study with a 2 × 2 factorial design. Lancet. 2022;399(10336):1695–707. https://doi.org/10.1016/S0140-6736(22)00367-1.
Smith MR, Hussain M, Saad F, Fizazi K, Sternberg CN, Crawford ED, et al. Darolutamide and survival in metastatic, hormone-sensitive prostate cancer. N Engl J Med. 2022. https://doi.org/10.1056/NEJMoa2119115.
Acknowlegdements
The authors would like to thank Stichting DUOS for their support.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Funding
Bayer provided funding for the preparation of this article.
Conflicts of Interest/Competing Interests
HW: honoraria; Astellas and Roche and travel expenses; Astellas and Ipsen. PH: consulting fees; Astellas, MSD, Pfizer, AstraZeneca, BMS and Ipsen. MPL: advisory role/speaker fees; Incyte, Amgen, Janssen Cilag B.V., Bayer, Servier, Roche, Pfizer Sanofi Aventis Netherlands BV and Astellas and has received research funding (institutional) from Sanofi, JnJ, Merck and Astellas. RDW: advisory role/speaker fees; Sanofi, Merck, Lilly, Roche, Bayer, Janssen Cilag B.V. and Clovis and research funding (institutional); Sanofi and Bayer. RHJM: has received research funding (institutional) from Bayer, Sanofi and Astellas.
Ethics Approval
Not applicable.
Consent to Participate
Not applicable.
Consent for Publication
Not applicable.
Availability of Data and Material
Not applicable.
Code Availability
Not applicable.
Authors’ Contributions
Conceptualisation: SB, RdW, RM; methodology: SB, RM, SK, PdB; formal analysis: SB, EOdH; investigation: SB, NG; resources: PdB, SB; data curation: SB, NG, writing, original draft: SB; writing, review and editing: all authors.
Supplementary Information
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Buck, S.A.J., Guchelaar, N.A.D., de Bruijn, P. et al. Influence of Darolutamide on Cabazitaxel Systemic Exposure. Clin Pharmacokinet 61, 1471–1473 (2022). https://doi.org/10.1007/s40262-022-01159-6
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s40262-022-01159-6