SpringerLink
Log in

Fabrication of a magnetite nanoparticle-loaded polymeric nanoplatform for magnetically guided drug delivery

  • Published:
Chemical Research in Chinese Universities Aims and scope

Abstract

We developed a magnetite nanoparticle-loaded polymeric nanoplatform for magnetically guided 10-hydroxycamptothecin(HCPT) delivery. The nanoplatform was fabricated by simultaneously incorporating magnetite nanoparticles(NPs) and HCPT into the polymer micelle self-assembled from methoxy polyethylene glycol-poly(D,L-lactide-co-glycolide)(MPEG-PLGA) copolymer. Successful loading of HCPT into the nanoplatform was confirmed by Fourier transform infrared(FTIR) spectroscopy. Subsequently, we examined the in vitro antitumor efficacy of free HCPT and nanoplatform against three different cancer cell lines—HeLa, A549 and HepG2. Flow cytometric analysis was conducted to reveal the cell apoptosis caused by free HCPT and nanoplatform. Finally, the magnetic targeting property of the nanoplatform was evaluated by a self-designed in vitro experiment.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Germany)

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Barreiro-Iglesias R., Bromberg L., Temchenko M., Hatton T. A., Concheiro A., Alvarez-Lorenzo C., J. Controlled Release, 2004, 97, 537

    Article  CAS  Google Scholar 

  2. Wang Y., Li L., Jiang W., Larrick J. W., Bioorgan. Med. Chem., 2005, 13, 5592

    Article  CAS  Google Scholar 

  3. Vladu B., Woynarowski J. M., Manikumar G., Wani M. C., Wall M. E., von Hoff D. D., Wadkins R. M., Mol. Pharmacol., 2000, 57, 243

    CAS  Google Scholar 

  4. Onishi H., Machida Y., Curr. Drug Discovery Technol., 2005, 2, 169

    Article  CAS  Google Scholar 

  5. Ertl B., Platzer P., Wirth M., Gabor F., J. Controlled Release, 1999, 61, 305

    Article  CAS  Google Scholar 

  6. Luo P., He Q., He X., Hu Y., Lu W., Cheng Y., Yang B., Mol. Cancer Ther., 2006, 5, 962

    Article  CAS  Google Scholar 

  7. Han M., He C. X., Fang Q. L., Yang X. C., Diao Y. Y., Xu D. H., He Q. J., Hu Y. Z., Liang W. Q., Yang B., Gao J. Q., Pharm. Res., 2009, 26(4), 926

    Article  CAS  Google Scholar 

  8. Li Q., Liu C., Zhao X., Zu Y., Wang Y., Zhang B., Zhao D., Zhao Q., Su L., Gao Y., Sun B., Int. J. Nanomed., 2011, 6, 397

    CAS  Google Scholar 

  9. Hu W., Zhang C., Fang Y., Lou C., Toxicol. in Vitro, 2011, 25, 513

    Article  CAS  Google Scholar 

  10. Pu X., Sun J., Wang Y., Wang Y., Liu X., Zhang P., Tang X., Pan W., Han J., He Z., Int. J. Pharm., 2009, 379(1), 167

    Article  CAS  Google Scholar 

  11. Yang X., Li L., Wang Y., Tan Y., Int. J. Pharm., 2009, 370, 210

    Article  CAS  Google Scholar 

  12. Watanabe M., Kawano K., Toma K., Hattori Y., Maitani Y., J. Controlled Release, 2008, 127, 231

    Article  CAS  Google Scholar 

  13. Hong M., Zhu S., Jiang Y. Y., Tang G. T., Pei Y. Y., J. Controlled Release, 2009, 133(2), 96

    Article  CAS  Google Scholar 

  14. Zhang G., Ding L., Renegar R., Wang X., Lu Q., Huo S., Chen Y. H., Cancer Sci., 2011, 102(6), 1216

    Article  CAS  Google Scholar 

  15. Morgan M. T., Nakanishi Y., Kroll D. J., Griset A. P., Carnahan M. A., Wathier M., Oberlies N. H., Manikumar G., Wani M. C., Grinstaff M. W., Cancer Res., 2006, 66, 11913

    Article  CAS  Google Scholar 

  16. Liu T. J., Liu S., Hu X. L., Sheng S. H., Huang Y. B., **g X. B., Chem. Res. Chinese Universities, 2011, 27(4), 628

    Google Scholar 

  17. Sutton D., Nasongkla N., Blanco E., Gao J. M., Pharm. Res., 2007, 24, 1029

    Article  CAS  Google Scholar 

  18. Miyata K., Christie R. J., Kataoka K., React. Funct. Polym., 2011, 71, 227

    Article  CAS  Google Scholar 

  19. Su P. F., Chen G., Zhao J., Chem. J. Chinese Universities, 2011, 32(7), 1472

    CAS  Google Scholar 

  20. Veiseh O., Gunn J. W., Zhang M., Adv. Drug Delivery Rev., 2010, 62, 284

    Article  CAS  Google Scholar 

  21. Lin X. L., Zhao S. H., Zhang L., Hu G. Q., Sun Z. W., Yang W. S., Chem. Res. Chinese Universities, 2012, 28(1), 114

    CAS  Google Scholar 

  22. Chomoucka J., Drbohlavova J., Huska D., Adam V., Kizek R., Hubalek J., Pharmacol. Res., 2010, 62, 144

    Article  CAS  Google Scholar 

  23. Sun S. H., Zeng H., Robinson D. B., Raoux S., Rice P. M., Wang S. X., Li G., J. Am. Chem. Soc., 2004, 126, 273

    Article  CAS  Google Scholar 

  24. Ding G. B., Guo Y., Lü Y. Y., Liu X. F., Xu L., Zhang X. Z., Colloids Surf., B, Biointerfaces, 2012, 91, 68

    Article  CAS  Google Scholar 

  25. ** C., Qian N., Zhao W., Yang W., Bai L., Wu H., Wang M., Song W., Dou K., Biomacromolecules, 2010, 11, 2422

    Article  CAS  Google Scholar 

  26. Fredenberg S., Wahlgren M., Reslow M., Axelsson A., Int. J. Pharm., 2011, 415, 34

    Article  CAS  Google Scholar 

  27. Wang J., Wang R., Li L. B., J. Colloid Interface Sci., 2009, 336, 808

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, College of Life Science, Jilin University, Changchun, 130012, P. R. China

    Guo-bin Ding, Yan Wang, Yan-yun Lü, Yi Guo & Li Xu

  2. College of Pharmacy, Jilin University, Changchun, 130021, P. R. China

    Yi Wu

  3. School of Stomatology, Dalian Medical University, Dalian, 116044, P. R. China

    Hui-ying Liu

Authors
  1. Guo-bin Ding
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hui-ying Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yan Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yan-yun Lü
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yi Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yi Guo
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Li Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Yi Wu or Yi Guo.

Additional information

Supported by the National Natural Science Foundation of China(Nos.30970719, 81000669), the Social Development Project of the Science and Technology Department of Jilin Province, China(No.20106031), the Project of Science and Technology Department of Changchun City, China(No.2009080-09SF02), the Specialized Research Fund for the Doctoral Program of Higher Education of China(No.20100061120077) and the China Postdoctoral Science Foundation(No.20100481048).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ding, Gb., Liu, Hy., Wang, Y. et al. Fabrication of a magnetite nanoparticle-loaded polymeric nanoplatform for magnetically guided drug delivery. Chem. Res. Chin. Univ. 29, 103–109 (2013). https://doi.org/10.1007/s40242-013-2134-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40242-013-2134-7

Keywords

Search

Navigation