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Comparison of stem cells derived from periosteum and bone marrow of jaw bone and long bone in rabbit models

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Tissue Engineering and Regenerative Medicine Aims and scope

Abstract

There is increasing interest in the therapeutic potential of stem cells because stem cells are promising candidates for the regeneration of tissue and treatment of diseases. Increasing evidence supports, multipotent stem cells may be obtained postnatally in different organs and tissues including bone marrow, synovium, adipose tissue, muscle and dental pulp. To determine a suitable cell source, the stem cells derived from periosteum and bone marrow of jaw bone(mandible) and long bone(tibia) were compared using rabbit models (JPO: periosteum from jaw-bone, JBM: bone marrow from jaw-bone, LPO: periosteum from long-bone, and LBM: bone marrow from long-bone). This study evaluated the proliferation and multilineage differentiation of the cells and clearly showed that expansion ability of JPO was higher than that of bone marrow derived cells. Comparisons of four different stem cells indicated that JPO group is the highest osteogenic potential. Moreover, this study has demonstrated that JPO, JBM and LBM are superior in terms of osteogensis and JPO, LPO and LBM are superior in terms of chondrogensis. Collectively, stem cells derived from jaw bone periosteium revealed highest osteogenic properties with relatively low morbidity with higher availability. Thus, it can be suggested that that periosteum from the jaw bone may be considered as optimal candidate for source of pluripotent stem cells with multi-germline potential with highest expansion ability and osteogenicity.

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Authors and Affiliations

  1. Department of Periodontics, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea

    Jun-Beom Park

  2. Division of Oral and Maxillofacial Surgery, Department of Dentistry, Uijongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea

    Sun-Sook Bae, Phil-Woo Lee, Won Lee, Yoon-Hee Park, Heesung Kim, KyoungHwa Lee & InSoo Kim

  3. Institute of Foreign Language Studies, Korea University, Seoul, Korea

    Heesung Kim

Authors
  1. Jun-Beom Park
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  2. Sun-Sook Bae
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  3. Phil-Woo Lee
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  4. Won Lee
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  5. Yoon-Hee Park
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  6. Heesung Kim
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  7. KyoungHwa Lee
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  8. InSoo Kim
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Correspondence to InSoo Kim.

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Park, JB., Bae, SS., Lee, PW. et al. Comparison of stem cells derived from periosteum and bone marrow of jaw bone and long bone in rabbit models. Tissue Eng Regen Med 9, 224–230 (2012). https://doi.org/10.1007/s13770-012-0343-7

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  • DOI: https://doi.org/10.1007/s13770-012-0343-7

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