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Meta-analysis of the association of prosaposin polymorphisms rs4747203 and rs885828 with risk of Parkinson’s disease

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Abstract

Background

Previous research has established a connection between polymorphisms rs4747203 and rs885828 in the prosaposin (PSAP) gene and an increased risk of Parkinson’s disease (PD). However, other studies have found no significant difference in risk compared to the general population.

Methods

To evaluate the current evidence linking rs4747203 and rs885828 to PD risk, we conducted a comprehensive search of PubMed, the Web of Science, Embase, and the Cochrane Library for relevant studies up until May 2023. In addition, we analyzed data from the publicly available “PD Variant Browser”. We performed a meta-analysis using Stata 17.0 to synthesize the findings from the selected studies.

Results

Our meta-analysis, which included data from six published studies and the public database, revealed no significant association between PD risk and either rs4747203 [OR (95% CI) = 0.99 (0.93–1.05), I2 = 90.3%, P = 0.635] or rs885828 [OR (95% CI) = 1.01 (0.95–1.07), I2 = 90.7%, P = 0.773]. These results remained consistent when examining subgroups of individuals within or outside of Asia.

Conclusion

The available evidence does not support an association between the genotype at rs4747203 or rs885828 and the risk of PD.

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Data availability

Data used in this article are included in the paper and available upon request with no restriction.

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Funding

This study was supported by Applied Basic Research Foundation of Yunnan Province [grant numbers:202201AS070164, **nglong Yang:202101AY070001-115], Yunnan Province Clinical Research Center for Geriatric Disease [grant number: 202102AA310069] and the **nglong Yang Joint Institute of Smoking and Health (No. 2021539200340039).

Author information

Authors and Affiliations

  1. Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, People’s Republic of China

    Liuhui Zhu, **nyue Zhang, Yongyun Zhu, Qian Zhou, Bin Liu, Hui Ren & **nglong Yang

  2. Joint Institute of Smoking and Health, Kunming, 650106, Yunnan, China

    Liuhui Zhu, Ying Guan & **nglong Yang

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  1. Liuhui Zhu
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  2. **nyue Zhang
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Contributions

XY, HR and BL contributed to the design. LZ and XZ participated in data collection and analysis. LZ, YZ and QZ written the manuscript. YG revised and improved the full text. All authors commented on previous versions of the manuscript and approved the final manuscript.

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Correspondence to **nglong Yang.

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Zhu, L., Zhang, X., Guan, Y. et al. Meta-analysis of the association of prosaposin polymorphisms rs4747203 and rs885828 with risk of Parkinson’s disease. Acta Neurol Belg 124, 573–580 (2024). https://doi.org/10.1007/s13760-023-02446-0

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