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Assessment of the cytotoxicity of silver-graphene oxide nanocomposites on Escherichia coli and glioblastoma cancer cells

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Abstract

In this research, we examined the toxicity of Ag-graphene oxide (GO) nanocomposites against both the Gram-negative bacterium Escherichia coli and Glioblastoma cancer cells (U87MG). Our findings reveal that Ag-GO possesses bactericidal properties, with a minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of 160 µg/mL. The antibacterial efficacy of Ag-GO is contingent on contact time and concentration, making it a potential candidate for integration into materials designed to combat microbial infections. The bactericidal effect of Ag-GO can be attributed to the release of silver ions and the physical damage inflicted by the sharp edges of GO sheets. Furthermore, our study demonstrates that Ag-GO exhibits anticancer activity against U87MG cells, with an IC50 value of 270 µg/mL. The mechanism underlying the anticancer activity of Ag-GO likely involves cell membrane disruption and apoptosis induction. These findings signify the promising medical and biological applications of Ag-graphene oxide nanocomposites.

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Acknowledgements

The authors gratefully acknowledge the financial support from the Ferdowsi University of Mashhad as well as Mashhad University of Medical Sciences.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, 9177948974, Iran

    Marjan Moghayedi & Elaheh K. Goharshadi

  2. Center of Nano Research, Ferdowsi University of Mashhad, Mashhad, 9177948974, Iran

    Elaheh K. Goharshadi

  3. Center for Nanotechnology in Renewable Energies, Ferdowsi University of Mashhad, Mashhad, 9177948974, Iran

    Elaheh K. Goharshadi

  4. Antimicrobial Resistance Research Center, Department of Microbiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, 13944-91388, Iran

    Kiarash Ghazvini

  5. Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran

    Laleh Ranjbaran

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  1. Marjan Moghayedi
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Contributions

Dr. Marjan Moghayedi: Data curation; Formal analysis; Investigation; Methodology; Resources; Software; Validation; Visualization; Roles/Writing—original draft; Writing—review & editing. Dr. Elaheh K. Goharshadi: Conceptualization; Data curation; Formal analysis; Funding acquisition; Investigation; Methodology; Project administration; Supervision; Validation; Visualization; Writing—review & editing. Dr. Kiarash Ghazvini: Conceptualization; Data curation; Formal analysis; Methodology; Project administration; Supervision; Validation; Visualization; Writing—review & editing. Laleh Ranjbaran: Investigation; Methodology; Software; Validation; Visualization; Roles/Writing—original draft.

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Correspondence to Elaheh K. Goharshadi.

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Moghayedi, M., Goharshadi, E.K., Ghazvini, K. et al. Assessment of the cytotoxicity of silver-graphene oxide nanocomposites on Escherichia coli and glioblastoma cancer cells. J IRAN CHEM SOC (2024). https://doi.org/10.1007/s13738-024-03013-x

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