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Synthesis and antioxidant screening of Novel indole amines

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Abstract

Novel indoles amines have been synthesized and screened for antioxidant activity. Chiron approach is used to synthesis enantiopure heterocycles. Newly synthesized indole amines showed good antioxidant potential as compared to standard drugs. Novel indole amines (13–17) were synthesized and showed promising DPPH• scavenging activity, The H2O2 inhibition potential and the Ferric ion (Fe3+) reducing antioxidant power assay. The pharmacological activity is tested by targeting indolic diazepines derivatives.

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Scheme 1
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Data availability

Samples of the compounds 4–17 are available from the authors.

Code availability

DPI = Compound no:4, LR89F = Compound no:6, LR_III_83A = Compound no:7 LR-89C = Compound no:9, LR-89D = Compound no:10, LR_SJ_I = Compound no:11, LR_SJ_V = Compound no:11, LR-52 = Compound no:13, LR_III_45B = Compound no:14, LR_III_60E = Compound no:15,, 2R = Compound no:16, LR-5R = Compound no:17.

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Acknowledgements

The authors acknowledge the Higher Education Commission (HEC) of Pakistan for generous financial support for research funding (HEC-20-3873). We are grateful to the University of Sargodha for the provision of basic instruments and the XRD facility.

Author information

Authors and Affiliations

  1. Department of Chemistry, Division of Science and Technology, University of Education, Lahore, 54770, Pakistan

    Syeda Laila Rubab

  2. Department of Chemistry, The University of Lahore, Sargodha Campus, Sargodha, 40100, Pakistan

    Bushra Nisar

  3. Institute of Chemistry, Ibn E Sina Block, University of Sargodha, Sargodha, 40100, Pakistan

    Abdul Rauf Raza

  4. Chemistry Department, Ghazi University, Dera Ghazi Khan (DGK), 32200, Pakistan

    Mubshara Saadia

  5. Department of Physics, University of Sargodha, Sargodha, 40100, Pakistan

    Muhammad Nawaz Tahir

  6. Department of Chemistry, The University of Lahore, Lahore, 5400, Pakistan

    Noreen Sajjad

  7. Nano and Hybrid Materials Laboratory, Department of Physics, Periyar University, Salem, Tamil Nadu, 636011, India

    Shanavas Shajahan

  8. PG and Research Department of Physics, Chikkaiah Naicker College, Erode, Tamil Nadu, 638004, India

    V. Sharmila

  9. Facultad de Ingenieria Y Tecnologia, Universidad San Sebastian, Bellavista 7, 84205254, Santiago, Chile

    Roberto Acevedo

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  1. Syeda Laila Rubab
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Contributions

SLR: Conception or design of the work, data collection, analysis and interpretation; BN: Conception or design of the work; ARR: Conception or design of the work; MS: Data analysis and interpretation; MNT: Data Collection; NS: Data Collection; SS: Final approval of the version to be published; RA: Final approval of the version to be published.

Corresponding authors

Correspondence to Syeda Laila Rubab or Roberto Acevedo.

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Rubab, S.L., Nisar, B., Raza, A.R. et al. Synthesis and antioxidant screening of Novel indole amines. J IRAN CHEM SOC 19, 2693–2704 (2022). https://doi.org/10.1007/s13738-021-02482-8

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  • DOI: https://doi.org/10.1007/s13738-021-02482-8

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